Ultrasound microscopy is the only technique that has the ability to monitor live-cell morphology over a long period of time without causing any damage to the cells, but its longer wavelength prevents one from obtaining high-resolution cell images. Here, we propose a deep-learning (DL) method for generating high-resolution acoustic images. By preparing datasets consisting of many pairs of acoustic and optical-microscope images for the same cells and training them, a high-resolution image comparable to optical microscopy is generated from an acoustic image. Importantly, the most accurate images are generated when three-layer (RGB) images containing not only high-frequency (approximately 180 MHz) images but also lower-frequency (approximately 100 MHz) images are used as the input images, which is attributed to enhanced acoustic absorption in the nucleus because the nucleus resonates in this low-frequency band. The DL scheme with the tri-frequency image input is applied to human mesenchymal stem cells and human induced pluripotent stem cells, and the high image-generation capability is demonstrated. As a result, high-resolution acoustic microscopy images are obtained for the same cells for over 24 h, without the typical cell damage encountered using optical imaging.

Through continuous progress in nuclear theory and experiment and an increasing number of neutron-star (NS) observations, a multitude of information about the equation of state (EOS) for matter at extreme densities is available. To constrain the EOS across its entire density range, this information needs to be combined consistently. However, the impact and model dependency of individual observations vary. Given their growing number, assessing the various methods is crucial to compare the respective effects on the EOS and discover potential biases. For this purpose, we present a broad compendium of different constraints and apply them individually to a large set of EOS candidates within a Bayesian framework. Specifically, we explore different ways of how chiral effective field theory and perturbative quantum chromodynamics can be used to place a likelihood on EOS candidates. We also investigate the impact of nuclear experimental constraints, as well as different radio and x-ray observations of NS masses and radii. This is augmented by reanalyses of the existing data from binary neutron star coalescences, in particular of GW170817, with improved models for the tidal waveform and kilonova light curves, which we also utilize to construct a tight upper limit of $2.39M_{\odot }$ on the TOV mass based on GW170817’s remnant. Our diverse set of constraints is eventually combined to obtain stringent limits on NS properties. We organize the combination in a way to distinguish between constraints where the systematic uncertainties are deemed small and those that rely on less conservative assumptions. For the former, we find the radius of the canonical $1.4M_{\odot }$ neutron star to be $R_{1.4}=12.26_{-0.91}^{+0.80}\mathrm{km}$ and the TOV mass at $M_{\mathrm{TOV}}=2.25_{-0.22}^{+0.42}{M}_{\odot }$ (95% credibility). Including all the presented constraints yields $R_{1.4}=12.20_{-0.48}^{+0.50}\mathrm{km}$ and $M_{\mathrm{TOV}}=2.30_{-0.20}^{+0.07}{M}_{\odot }$. When comparing these limits to individual data points, we find that the quoted radius of HESS J1731-347 displays noticeable tension with other constraints. Constraining microphysical properties of the EOS proves more challenging. For instance, the symmetry energy slope is restricted to $L_{\mathrm{sym}}={48}_{-25}^{+21}\mathrm{MeV}$, where this constraint is mainly dominated by our reanalysis of the PREX-II and CREX experiment.

Despite their importance in quantum theory, joint quantum measurements remain poorly understood. An intriguing conceptual and practical question is whether joint quantum measurements on separated systems can be performed without bringing them together. Remarkably, by using shared entanglement, this can be achieved perfectly when disregarding the postmeasurement state. However, existing localization protocols typically require unbounded entanglement. In this work, we address the fundamental question: “Which joint measurements can be localized with a finite amount of entanglement?” We develop finite-resource versions of teleportation-based schemes and analytically classify all two-qubit measurements that can be localized in the first levels of the resulting hierarchies. These levels include several measurements with exceptional properties and symmetries, such as the Bell state measurement and the elegant joint measurement. This leads us to propose a systematic classification of joint measurements based on entanglement cost, which we argue directly connects with the complexity of implementing those measurements. We illustrate how to numerically explore higher levels and construct generalizations to higher dimensions and multipartite settings.

Gravitational waves, detected a century after they were first theorized, are space-time distortions caused by some of the most cataclysmic events in the Universe, including black hole mergers and supernovae. The successful detection of these waves has been made possible by ingenious detectors designed by human experts. Beyond these successful designs, the vast space of experimental configurations remains largely unexplored, offering an exciting territory potentially rich in innovative and unconventional detection strategies. Here, we demonstrate an intelligent computational strategy to explore this enormous space, discovering unorthodox topologies for gravitational wave detectors that significantly outperform the currently best-known designs under realistic experimental constraints. This increases the potentially observable volume of the Universe by up to 50-fold. Moreover, by analyzing the best solutions from our superhuman algorithm, we uncover entirely new physics ideas at their core. At a bigger picture, our methodology can readily be extended to AI-driven design of experiments across wide domains of fundamental physics, opening fascinating new windows into the Universe.

Solid-state quantum registers consisting of optically active electron spins with nearby nuclear spins are promising building blocks for future quantum technologies. For electron spin-1 registers, dynamical decoupling (DD) quantum gates have been developed that enable the precise control of multiple nuclear spin qubits. However, for the important class of electron spin-$1/2$ systems, this control method suffers from intrinsic selectivity limitations, resulting in reduced nuclear spin gate fidelities. Here, we demonstrate improved control of single nuclear spins by an electron spin-$1/2$ using dynamically decoupled radio-frequency (DDRF) gates. We make use of the electron spin-$1/2$ of a diamond tin-vacancy center, showing high-fidelity single-qubit gates, single-shot readout, and spin coherence beyond a millisecond. The DD control is used as a benchmark to observe and control a single ${}^{1}3\mathrm{C}$ nuclear spin. Using the DDRF control method, we demonstrate improved control on that spin. In addition, we find and control an additional nuclear spin that is insensitive to the DD control method. Using these DDRF gates, we show entanglement between the electron and the nuclear spin with 72(3)% state fidelity. Our extensive simulations indicate that DDRF gate fidelities well in excess are feasible. Finally, we employ time-resolved photon detection during readout to quantify the hyperfine coupling for the electron’s optically excited state. Our work provides key insights into the challenges and opportunities for nuclear spin control in electron spin-$1/2$ systems, opening the door to multiqubit experiments on these promising qubit platforms.

Although spin and charge stripes in high-$T_c$ cuprates have been extensively studied, the exact range of carrier concentration over which they form a static order remains uncertain, complicating efforts to understand their significance. The problem is challenging due to the combined effects of quenched disorder and competition with superconductivity—both significant in cuprates—which add to the inherent difficulty of determining phase boundaries. In ${\mathrm{La}}_{2-x}{\mathrm{Sr}}_x{\mathrm{CuO}}_4$ (LSCO) and in zero external magnetic field, static spin stripes are confined to a doping range well below $p^{*}$, the pseudogap boundary at zero temperature. However, when high fields suppress the competing effect of superconductivity, spin-stripe order is found to extend up to $p^{*}$. Here, we investigate ${\mathrm{La}}_{1.8-x}{\mathrm{Eu}}_{0.2}{\mathrm{Sr}}_x{\mathrm{CuO}}_4$ (Eu-LSCO) using ${}^{139}\mathrm{La}$ nuclear magnetic resonance and observe field-dependent spin fluctuations suggesting a similar competition between superconductivity and spin order as in LSCO. Nevertheless, we find that static spin stripes are present practically up to $p^{*}$ irrespective of field strength: The stronger stripe order in Eu-LSCO prevents superconductivity from enforcing a nonmagnetic ground state, except very close to $p^{*}$. Thus, spin-stripe order is consistently bounded by $p^{*}$ in both LSCO and Eu-LSCO, despite their differing balances between stripe order and superconductivity. This indicates that the canonical stripe order, where spins and charges are intertwined in a static pattern, is fundamentally tied to the pseudogap phase, though the exact nature of this connection has yet to be elucidated. Any stripe order beyond the pseudogap endpoint must then be of a different nature: Either spin and charge orders remain intertwined, but both fluctuating, or only spin order fluctuates while charge order remains static. The presence of spin-stripe order up to $p^{*}$ and the pervasive, slow, and field-dependent spin-stripe fluctuations, as well as the electronic inhomogeneity documented in this work, must all be carefully considered in discussions of Fermi surface transformations, putative quantum criticality, and strange metal behavior.

Spins and oscillators are foundational to much of physics and applied sciences. For quantum information, a spin $1/2$ exemplifies the most basic unit, a qubit. High angular momentum spins (HAMSs) and harmonic oscillators provide multilevel manifolds which have the potential for hardware-efficient protected encodings of quantum information and simulation of many-body quantum systems. In this work, we demonstrate a new quantum control protocol that conceptually merges these disparate hardware platforms. Namely, we show how to modify a harmonic oscillator on demand to implement a continuous range of generators to accomplish linear and nonlinear HAMS dynamics. The spinlike dynamics are verified by demonstration of linear spin coherent [SU(2)] rotations, nonlinear spin rotations, and comparison to other manifolds like simply truncated oscillators. Our scheme allows universal control of a spin cat logical qubit encoding with interpretable drive pulses: We use linear operations to accomplish four logical gates and further show that nonlinear spin rotations can complete the logical gate set. Our results show how motion on a closed Hilbert space can be useful for quantum information processing and opens the door to superconducting circuit simulations of higher angular momentum quantum magnetism.

The discovery of superconductivity in pressurized bilayer and trilayer nickelates has generated significant interest. However, their superconducting properties are often dependent on sample quality and pressure conditions, complicating the interpretation of the underlying physics. Finding new systems with optimized bulk superconducting properties is therefore important for advancing our understanding of these materials. Unlike cuprates, where trilayer compounds typically exhibit the highest transition temperature ($T_c$), the bilayer nickelate ${\mathrm{La}}_3{\mathrm{Ni}}_2{\mathrm{O}}_7$ has thus far outperformed the trilayer ${\mathrm{La}}_4{\mathrm{Ni}}_3{\mathrm{O}}_{10}$ in reported $T_c$. Whether the trilayer nickelates have achieved the optimal $T_c$ remains unclear, with various scenarios suggesting different possibilities. Here, we report the discovery of bulk superconductivity in pressurized ${\mathrm{Pr}}_4{\mathrm{Ni}}_3{\mathrm{O}}_{10}$ single crystals, achieving a maximum onset $T_c$ of 40.5 K at 80.1 GPa, significantly exceeding the 30 K observed in ${\mathrm{La}}_4{\mathrm{Ni}}_3{\mathrm{O}}_{10}$. The bulk nature of superconductivity is confirmed by zero resistance and a strong diamagnetic response below $T_c$, with a superconducting volume fraction exceeding 80%. These findings establish trilayer nickelates as genuine bulk high-temperature superconductors, provide new insights into the mechanisms driving superconductivity, and point to a promising route toward further enhancing superconducting properties in nickelates.

Couplings between biochemical and mechanical processes have a profound impact on embryonic development. However, in vitro studies capable of quantifying these interactions have remained elusive. Here, we investigate a synthetic system where a DNA reaction-diffusion (RD) front is advected by a turbulent flow generated by active matter (AM) flows in a quasi-one-dimensional geometry. Whereas the dynamics of simple RD fronts solely depend on the reaction and diffusion rates, we show that RD-AM front propagation is also influenced by the confinement geometry. We first experimentally dissected the different components of the reaction-diffusion-advection process by knocking out reaction or advection and observe how RD-AM allows for faster transport over large distances, avoiding dilution. We then show how confinement impacts active matter flow: While changes in instantaneous flow velocities are small, correlation times are dramatically increased with decreasing confinement. As a result, RD-AM front speed increases up to eightfold compared to an RD one, in quantitative agreement with a conveyor-belt reaction-diffusion-advection theoretical model. The RD-AM experimental system described here provides a framework for the rational engineering of complex spatiotemporal processes observed in living systems. It will reinforce our understanding of how macro-scale patterns and structures emerge from microscopic components in nonequilibrium systems.

The adhesion between dry solid surfaces is typically governed by contact forces, involving surface forces and elasticity. For surfaces immersed in a fluid, out-of-contact adhesion arises due to the viscous resistance to the opening of the liquid gap. While the adhesion between dry solids is described by the classical Johnson-Kendall-Roberts (JKR) theory, there is no equivalent framework for the wet adhesion of soft solids. Here, we investigate theoretically the viscous adhesion emerging during the separation of a sphere from an elastic substrate. The suction pressure within the thin viscous film between the solids induces significant elastic displacements. Unexpectedly, the elastic substrate closely follows the motion of the sphere, leading to a sticking without contact. The initial dynamics is described using similarity solutions, resulting in a nonlinear adhesion force that grows in time as $F\propto t^{2/3}$. When elastic displacements become large enough, another similarity solution emerges that leads to a violent snap-off of the adhesive contact through a finite-time singularity. The observed phenomenology bears a strong resemblance with JKR theory and is relevant for a wide range of applications involving viscous adhesion.

Nickelate superconductors have attracted a great deal of attention over the past few decades due to their similar crystal and electronic structures with high-temperature cuprate superconductors. Here, we report superconductivity in a pressurized Ruddlesden-Popper phase single crystal ${\mathrm{La}}_4{\mathrm{Ni}}_3{\mathrm{O}}_{10}(n=3)$ and its interplay with the density wave order in the phase diagram. With increasing pressure, the density wave order, as indicated by the anomaly in the resistivity, is progressively suppressed, followed by the emergence of superconductivity around 25 K under the $I4/mmm$ space group. The susceptibility measurements confirm bulk superconductivity with a volume fraction exceeding 80%. Moreover, theoretical analysis unveils that antiferromagnetic superexchange interactions can serve as the effective pairing interaction for the emergence of superconductivity in pressurized ${\mathrm{La}}_4{\mathrm{Ni}}_3{\mathrm{O}}_{10}$. Our research provides a new platform for the investigation of the unconventional superconductivity mechanism in Ruddlesden-Popper trilayer perovskite nickelates.

A central spin qubit interacting coherently with an ensemble of proximal spins can be used to engineer entangled collective states or a multiqubit register. Making full use of this many-body platform requires tuning the interaction between the central spin and its spin register. GaAs quantum dots offer a model realization of the central spin system where an electron qubit interacts with multiple ensembles of $\sim {10}^4$ nuclear spins. In this work, we demonstrate tuning of the interaction between the electron qubit and the nuclear many-body system in a GaAs quantum dot. The homogeneity of the GaAs system allows us to perform high-precision and isotopically selective nuclear sideband spectroscopy, which reveals the single-nucleus electronic Knight field. Together with time-resolved spectroscopy of the nuclear field, this fully characterizes the electron-nuclear interaction for a priori control. An algorithmic feedback sequence selects the nuclear polarization precisely, which adjusts the electron-nuclear exchange interaction in situ via the electronic $g$-factor anisotropy. This allows us to tune directly the activation rate of a collective nuclear excitation (magnon) and the coherence time of the electron qubit. Our method is applicable to similar central-spin systems and enables the programmable tuning of coherent interactions in the many-body regime.

Bosonic pure-loss channel, which represents the process of photons decaying into a vacuum environment, has zero quantum capacity when the channel’s transmissivity is less than 50%. Modeled as a beam splitter interaction between the system and its environment, the performance of bosonic pure-loss channel can be enhanced by controlling the environment state. We show that by choosing the ideal Gottesman-Kitaev-Preskill (GKP) states for the system and its environment, perfect transmission of quantum information through a beam splitter is achievable at arbitrarily low transmissivities. Our explicit constructions allow for experimental demonstration of the improved performance of a quantum channel through passive environment assistance, which is potentially useful for quantum transduction where the environment state can be naturally controlled. In practice, it is crucial to consider finite-energy constraints, and high-fidelity quantum communication through a beam splitter remains achievable with GKP states at the few-photon level.

We use nonlinear pump-probe spectroscopy to study optical excitations in a charge-tunable ${\mathrm{MoSe}}_2/{\mathrm{WS}}_2$ moiré heterostructure. An intense red-detuned laser pulse creates a photonic dressing of the material by introducing a large virtual population of excitons or exciton polarons in a deep moiré potential. By measuring the resulting ac Stark effect with a weak resonant laser pulse, we gain access to the nature and mutual interactions of the elementary optical excitations. At charge neutrality, our measurements reveal that different exciton resonances, associated with confinement of their center-of-mass motion in the moiré potential, have a significant spatial overlap. The resulting short-range interactions manifest themselves as a density-dependent blueshift for same-valley excitons and bound biexciton states for opposite-valley excitons. The attractive polaron resonance that appears upon injection of electrons into the heterostructure shows a contrasting behavior: Here, we observe an electron-density-independent light shift and a clear pump-power-dependent saturation. These features are equivalent to that of an ensemble of independent two-level emitters and indicate a breakdown of the Fermi-polaron picture for optical excitations of electrons subject to a strong moiré potential. Our work establishes an experimental approach to elucidate the elementary optical excitations of semiconductor moiré heterostructures, providing a solid ground for the spectroscopy of correlated electronic and excitonic states in such materials.

Electron-boson coupling in unconventional superconductors is one of the key parameters in understanding the superconducting pairing symmetry. Here, we report definitive photoemission evidence of electron-spin fluctuation coupling in the iron-based superconductor ${\mathrm{CaKFe}}_4{\mathrm{As}}_4$, obtained via high-resolution ARPES. Our study identifies a distinct kink structure on the $\alpha$ band, observable only in the superconducting phase and closely linked with the superconductivity, indicative of strong electron-boson interactions. Notably, this kink structure corresponds to two distinct bosonic modes at 11 meV and 13 meV, aligning with spin resonance modes previously observed in inelastic neutron-scattering experiments. This alignment underscores the significant role of antiferromagnetic fluctuations in the pairing mechanism of this superconductor. Furthermore, the unique momentum-dependent and orbital-selective properties of the coupling revealed by ARPES provide profound insights into the pairing symmetry, suggesting predominantly $s_{\pm }$-wave pairing facilitated by spin fluctuations. Our findings not only highlight the pivotal role of spin resonance in the superconductivity of ${\mathrm{CaKFe}}_4{\mathrm{As}}_4$ but also enhance our understanding of the electron-spin fluctuation interactions in unconventional superconductors.

Most approaches for designing self-assembled materials focus on the thermodynamic stability of a target structure or crystal polymorph. Yet in practice, the outcome of a self-assembly process is often controlled by kinetic pathways. Here we present an efficient machine-learning-guided design algorithm to identify globally optimal interaction potentials that maximize both the thermodynamic yield and kinetic accessibility of a target polymorph. We show that optimal potentials exist along a Pareto front, indicating the possibility of a trade-off between the thermodynamic and kinetic objectives. Although the extent of this trade-off depends on the target polymorph and the assembly conditions, we generically find that the trade-off arises from a competition among alternative polymorphs: The most kinetically optimal potentials, which favor the target polymorph on short timescales, tend to stabilize a competing polymorph at longer times. Our work establishes a general-purpose approach for multiobjective self-assembly optimization, reveals fundamental trade-offs between crystallization speed and defect formation in the presence of competing polymorphs, and suggests guiding principles for materials design algorithms that optimize for kinetic accessibility.

Landau’s Fermi-liquid (FL) theory has been successful at the phenomenological description of the normal phase of many different Fermi systems. Using a dilute atomic Fermi fluid with tunable interactions, we investigate the microscopic basis of Landau’s theory with a system describable from first principles. We study transport properties of an interacting Fermi gas by measuring its density response to a periodic external perturbation. In an ideal Fermi gas, we measure for the first time the celebrated Lindhard function. As the system is brought from the collisionless to the hydrodynamic regime, we observe the emergence of sound and find that the experimental observations are quantitatively understood with a first-principle transport equation for the FL. When the system is more strongly interacting, we find deviations from such predictions. Finally, we measure the momentum-space shape of the quasiparticle excitations and see how it evolves from the collisionless to the collisional regime. Our study establishes this system as a clean platform for studying Landau’s theory of the FL and paves the way for extending the theory to more exotic conditions, such as nonlinear dynamics and FLs with strong correlations in versatile settings.

The novel concept of entanglement renormalization and its corresponding tensor network renormalization technique have been highly successful in developing a controlled real-space renormalization group (RG) scheme. Numerically approximate fixed-point (FP) tensors are widely used to extract the conformal data of the underlying conformal field theory (CFT) describing critical phenomena. In this paper, we present an explicit analytical construction of the FP tensor for 2D rational CFT. We define it as a correlation function between the “boundary-changing operators” (BCO) on triangles. Our construction fully captures all the real-space RG conditions. We also provide concrete examples, such as Ising, Yang-Lee, and tricritical Ising models, to compute the scaling dimensions explicitly based on the corresponding FP tensor. The BCO descendants turn out to be an optimal basis such that truncation in bond dimensions naturally produces comparable accuracies with the leading existing FP algorithms. Interestingly, our construction of FP tensors is closely related to a strange correlator, where the holographic picture naturally emerges. Our results also open a new door toward understanding CFT in higher dimensions.

Following a consistent geometrical description previously introduced [Quantum 8, 1466 (2024)], we present an exact method for obtaining canonically quantizable Hamiltonian descriptions of nonlinear, nonreciprocal quasilumped electrical networks. We identify and classify singularities arising in the quest for Hamiltonian descriptions of general quasilumped element networks via the Faddeev-Jackiw technique. We offer systematic solutions to cases previously considered singular—a major challenge in the context of canonical circuit quantization. The solution relies on the correct identification of the reduced classical circuit-state manifold, i.e., a mix of flux and charge fields and functions. Starting from the geometrical description of the transmission line, we provide a complete program including lines coupled to one-port lumped-element networks, as well as multiple lines connected to multiport nonreciprocal lumped-element networks, with intrinsic ultraviolet cutoff. On the way, we naturally extend the canonical quantization of transmission lines coupled through frequency-dependent, nonreciprocal linear systems, such as practical circulators. Additionally, we demonstrate how our method seamlessly facilitates the characterization of general nonreciprocal, dissipative linear environments. This is achieved by extending the Caldeira-Leggett formalism, using continuous limits of series of immittance matrices. We provide a tool in the analysis and design of electrical circuits and of special interest in the context of canonical quantization of superconducting networks. For instance, this work provides a solid ground for a precise nondivergent input-output theory in the presence of nonreciprocal devices, e.g., within (chiral) waveguide QED platforms.

Entanglement between photons and a quantum memory is a key component of quantum repeaters, which allow long-distance quantum entanglement distribution in the presence of fiber losses. Spin-photon entanglement has been implemented with a number of different atomic and solid-state qubits with long spin coherence times, but none directly emit photons into the $1.5\text{−}\mathrm{\mu }\mathrm{m}$ telecom band where losses in optical fibers are minimized. Here, we demonstrate spin-photon entanglement using a single rare earth ion in the solid-state ${\mathrm{Er}}^{3+}$ coupled to a silicon nanophotonic cavity, which directly emits photons at 1532.6 nm. We infer an entanglement fidelity of 73(3)% after propagating through 15.6 km of optical fiber. This work opens the door to large-scale quantum networks based ${\mathrm{Er}}^{3+}$ ions, leveraging scalable silicon device fabrication and spectral multiplexing.