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Enzymatically Driven Remodeling of Growth Kinetics and Internal Structure in Biomolecular Condensates

Tamizhmalar Sundararajan, Matteo Boccalini, Roméo Suss, Sandrine Mariot, Emerson R. Da Silva, Fernando C. Giacomelli, Austin Hubley, Theyencheri Narayanan, Alessandro Barducci, and Guillaume Tresset

PRX Life 4, 043001 (2026) - Published 8 October, 2026

Time-resolved scattering uncovers how enzymatic activity redirects the assembly pathway of biomolecular condensates, creating distinct internal structures and dynamics.

Volatile But Persistent Coexistence of Self-Compatibility and Self-Incompatibility in Plants

Amit Jangid, Ohad Noy Feldheim, and Tamar Friedlander

PRX Life 4, 043005 (2026) - Published 26 October, 2026

Plants may not have to choose between selfing and outcrossing: a biophysical evolutionary model reveals a persistent mixed-mating state whose composition continues to fluctuate without settling—even in an unchanging environment—and predicts, counterintuitively, that pollen scarcity can favor self-incompatibility.

Capillary Bundling of Microtubules by Condensates

Bernardo Gouveia, J. Pedro de Souza, Venecia A. Valdez, Joshua W. Shaevitz, Howard A. Stone, and Sabine Petry

PRX Life 4, 043006 (2026) - Published 27 October, 2026

By combining experiments and theory, this study establishes condensate-mediated capillary forces as a distinct mechanism for microtubule bundling.

Decoding Social Integration in Schooling Fish Using Closed-Loop Real-Virtual Interactions

Zhen Kang, Ramón Escobedo, Maud Combe, Stéphane Sanchez, Clément Sire, and Guy Theraulaz

PRX Life 4, 043007 (2026) - Published 29 October, 2026

Schooling fish coordinate their motion with a single dynamically selected neighbor—the one exerting the strongest influence, not necessarily the closest one.

ARTICLES

Enzymatically Driven Remodeling of Growth Kinetics and Internal Structure in Biomolecular Condensates

Tamizhmalar Sundararajan, Matteo Boccalini, Roméo Suss, Sandrine Mariot, Emerson R. Da Silva, Fernando C. Giacomelli, Austin Hubley, Theyencheri Narayanan, Alessandro Barducci, and Guillaume Tresset

PRX Life 4, 043001 (2026) - Published 8 October, 2026

Time-resolved scattering uncovers how enzymatic activity redirects the assembly pathway of biomolecular condensates, creating distinct internal structures and dynamics.

Mechanosensitive Remodeling Sustains Rigidity Homeostasis and Elastic Memory in Actin Cortex Models

Haina Wang, Marco A. Galvani Cunha, John C. Crocker, and Andrea J. Liu

PRX Life 4, 043002 (2026) - Published 15 October, 2026

The actin cortex stays rigid and retains elastic memory not by staying still but by continuously remodeling itself, recycling its components in response to mechanical forces.

Reconstruction of the Bacterial Flagellar Motor's Energy Landscape, Viscous Load, and Torque Generation Across Diffusion Regimes

N. J. López-Alamilla, A. L. Nord, F. Pedaci, J. Palmeri, and N.-O. Walliser

PRX Life 4, 043003 (2026) - Published 23 October, 2026

Fluctuations are more than noise—they provide a window into the energy landscape and friction governing the bacterial flagellar motor.

Characterizing Nonlinear Dynamics via Smooth Prototype Equivalences

Roy Friedman, Noa Moriel, Matthew Ricci, Guy Pelc, Yair Weiss, and Mor Nitzan

PRX Life 4, 043004 (2026) - Published 26 October, 2026

By mapping sparse observations to prototypical behaviors, this equation-free framework identifies driving marker genes and traces cell-cycle trajectories directly from high-dimensional single-cell gene expression data.

Volatile But Persistent Coexistence of Self-Compatibility and Self-Incompatibility in Plants

Amit Jangid, Ohad Noy Feldheim, and Tamar Friedlander

PRX Life 4, 043005 (2026) - Published 26 October, 2026

Plants may not have to choose between selfing and outcrossing: a biophysical evolutionary model reveals a persistent mixed-mating state whose composition continues to fluctuate without settling—even in an unchanging environment—and predicts, counterintuitively, that pollen scarcity can favor self-incompatibility.

Capillary Bundling of Microtubules by Condensates

Bernardo Gouveia, J. Pedro de Souza, Venecia A. Valdez, Joshua W. Shaevitz, Howard A. Stone, and Sabine Petry

PRX Life 4, 043006 (2026) - Published 27 October, 2026

By combining experiments and theory, this study establishes condensate-mediated capillary forces as a distinct mechanism for microtubule bundling.

Decoding Social Integration in Schooling Fish Using Closed-Loop Real-Virtual Interactions

Zhen Kang, Ramón Escobedo, Maud Combe, Stéphane Sanchez, Clément Sire, and Guy Theraulaz

PRX Life 4, 043007 (2026) - Published 29 October, 2026

Schooling fish coordinate their motion with a single dynamically selected neighbor—the one exerting the strongest influence, not necessarily the closest one.

Born to Condense: Polysomes Drive Cotranslational Condensation of Biomolecular Condensate Proteins

Zhouyi He (贺周易), Chi Fung Willis Chow, Agnes Toth-Petroczy, Jens-Uwe Sommer, and Tyler S. Harmon

PRX Life 4, 043008 (2026) - Published 30 October, 2026

Translation is more than making proteins—it can actively drive their localization to biomolecular condensates as they emerge from polysomes.

Defect States in Compressible Active Polar Fluids with Renewal

Ludovic Dumoulin, Carles Blanch-Mercader, and Karsten Kruse

PRX Life 4, 043009 (2026) - Published 3 November, 2026

Material renewal stabilizes defects that organize active stress in cells and tissues.

Independent Training Trajectories Learn the Same Interaction Parameters in Coarse-Grained Protein Models

Marcos Lequerica-Mateos, Jonathan Martin, José N. Onuchic, Faruck Morcos, and Ivan Coluzza

PRX Life 4, 043010 (2026) - Published 4 November, 2026

A self-consistent training framework that learns residue-residue interactions in proteins bridges sequence statistics and physically modeled interaction energies.

Nonlinear Competition Avoidance Favors Coexistence in Spatially Structured Microbial Populations

Mattia Mattei, David Soriano-Paños, and Alex Arenas

PRX Life 4, 043011 (2026) - Published 5 November, 2026

By increasing their motility nonlinearly in response to competitor density, interacting microbial populations spontaneously segregate to form emergent spatial patterns that sustain long-term coexistence.

Mechanics of Axis Formation in Hydra

Arthur Hernandez, Cuncheng Zhu, and Luca Giomi

PRX Life 4, 043012 (2026) - Published 10 November, 2026

Mechanics plays a crucial role in the formation of the head-foot axis in Hydra, where contractile muscle fibers and the topology of nematic defects concentrate stress to generate the strain and pressure asymmetries needed for head and foot formation.

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