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  • Open Access

Critical-like growth in noncritical transitions: Linearized dynamics and epidemic applications

Joshua Looker1, Kat S. Rock2, and Louise Dyson2,3

  • 1EPSRC and MRC Centre for Doctoral Training in Mathematics for Real-World Systems, University of Warwick, Coventry, England, United Kingdom
  • 2The Zeeman Institute for Systems Biology and Infectious Disease Epidemiology Research, and Mathematics Institute, University of Warwick, Coventry, England, United Kingdom
  • 3School of Life Sciences, University of Warwick, Coventry, England, United Kingdom

Phys. Rev. E 114, 044205 – Published 9 October, 2026

DOI: https://doi.org/10.1103/2fyp-hjbd

Abstract

In the wake of the SARS-CoV-2 pandemic, there has been heightened interest from applied mathematicians in infectious disease modeling. Modeling efforts often focus on predicting whether diseases are likely to be eliminated or, instead, (re)emerge, especially as a result of control measures. This tipping point between elimination and infection waves has been successfully anticipated in the literature through the use of early warning signals and such signals often rely on the theory of critical slowing down. Recent developments have shown that these signals (increases in fluctuation variance and return time) can emerge from the system geometry in the case of non-normal dynamics rather than a change in asymptotic stability. We show how such dynamical behavior occurs in the fluctuations from the mean field in general stochastic systems. Using the susceptible-infectious-recovered model as an example application, we analyze how critical-like behavior can be exploited to anticipate infection waves in the absence of an equilibrium bifurcation.

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References (40)

  1. T. S. Brett, J. M. Drake, and P. Rohani, Anticipating the emergence of infectious diseases, J. R. Soc. Interface. 14, 20170115 (2017).
  2. T. S. Brett, E. B. O'Dea, É. Marty, P. B. Miller, A. W. Park, J. M. Drake, P. Rohani, and M. Pascual, Anticipating epidemic transitions with imperfect data, PLoS Comput. Biol. 14, e1006204 (2018).
  3. J. Looker, K. S. Rock, and L. Dyson, Identifying COVID-19 peaks using early warning signals, PLoS Comput. Biol. 21, e1013524 (2025).
  4. E. Southall, T. S. Brett, M. J. Tildesley, and L. Dyson, Early warning signals of infectious disease transitions: A review, J. R. Soc. Interface. 18, 20210555 (2021).
  5. E. Southall, M. J. Tildesley, and L. Dyson, Prospects for detecting early warning signals in discrete event sequence data: Application to epidemiological incidence data, PLoS Comput. Biol. 16, e1007836 (2020).
  6. A. Gama Dessavre, E. Southall, M. J. Tildesley, and L. Dyson, The problem of detrending when analysing potential indicators of disease elimination, J. Theor. Biol. 481, 183 (2019).
  7. A. Ghadami, E. B. O'Dea, J. M. Drake, P. Rohani, and B. I. Epureanu, Anticipating epidemic transitions in metapopulations with multivariate spectral similarity, Nonlinear Dyn. 111, 17605 (2023).
  8. J. M. Drake, T. S. Brett, S. Chen, B. I. Epureanu, M. J. Ferrari, É. Marty, P. B. Miller, E. B. O'Dea, S. M. O'Regan, A. W. Park, P. Rohani, and R. R. Regoes, The statistics of epidemic transitions, PLoS Comput. Biol. 15, e1006917 (2019).
  9. C. Kuehn, A mathematical framework for critical transitions: Bifurcations, fast–slow systems and stochastic dynamics, Physica D 240, 1020 (2011).
  10. V. Troude, S. C. Lera, K. Wu, and D. Sornette, Pseudo-bifurcations in stochastic non-normal systems and the limits of early-warning signals, Commun. Phys. 9, 289 (2026).
  11. S. M. O'Regan, E. B. O'Dea, P. Rohani, and J. M. Drake, Transient indicators of tipping points in infectious diseases, J. R. Soc. Interface. 17, 20200094 (2020).
  12. D. Proverbio, F. Kemp, S. Magni, J. Gonçalves, and B. Althouse, Performance of early warning signals for disease re-emergence: A case study on COVID-19 data, PLoS Comput. Biol. 18, e1009958 (2022).
  13. F. Dablander, H. Heesterbeek, D. Borsboom, and J. M. Drake, Overlapping timescales obscure early warning signals of the second COVID-19 wave, Proc. R. Soc. B 289, 20211809 (2022).
  14. T. Kaur, S. Sarkar, S. Chowdhury, S. K. Sinha, M. K. Jolly, and P. S. Dutta, Anticipating the novel coronavirus disease (COVID-19) pandemic, Front. Public Health 8, 569669 (2020).
  15. L. N. Trefethen and M. Embree, Spectra and Pseudospectra: The Behavior of Nonnormal Matrices and Operators (Princeton University, Princeton, NJ, 2005).
  16. B. F. Farrell and P. J. Ioannou, Generalized stability theory. Part I: Autonomous operators, J. Atmos. Sci. 53, 2025 (1996).
  17. B. F. Farrell and P. J. Ioannou, Generalized stability theory. Part II: Nonautonomous operators, J. Atmos. Sci. 53, 2041 (1996).
  18. G. Rozhnova, A. Nunes, and A. J. McKane, Phase lag in epidemics on a network of cities, Phys. Rev. E 85, 051912 (2012).
  19. G. Rozhnova, A. Nunes, and A. J. McKane, Stochastic oscillations in models of epidemics on a network of cities, Phys. Rev. E 84, 051919 (2011).
  20. G. Rozhnova and A. Nunes, Stochastic effects in a seasonally forced epidemic model, Phys. Rev. E 82, 041906 (2010).
  21. G. Rozhnova and A. Nunes, Fluctuations and oscillations in a simple epidemic model, Phys. Rev. E 79, 041922 (2009).
  22. S. M. O'Regan and J. M. Drake, Theory of early warning signals of disease emergence and leading indicators of elimination, Theor. Ecol. 6, 333 (2013).
  23. P. B. Miller, E. B. O'Dea, P. Rohani, and J. M. Drake, Forecasting infectious disease emergence subject to seasonal forcing, Theor. Biol. Med. Modell. 14, 17 (2017).
  24. S. M. O'Regan, J. W. Lillie, and J. M. Drake, Leading indicators of mosquito-borne disease elimination, Theor. Ecol. 9, 269 (2016).
  25. G. M. Donovan, Characterising early warning signals for critical transitions using a distribution moment approximation for the Fokker–Planck equation, Physica A 646, 129868 (2024).
  26. H. Abou-Kandil, G. Freiling, V. Ionescu, and G. Jank, in Matrix Riccati Equations in Control and Systems Theory, edited by T. Başar, Systems and Control: Foundations and Applications (Birkhäuser, Basel, 2003).
  27. M. Behr, P. Benner, and J. Heiland, Solution formulas for differential Sylvester and Lyapunov equations, Calcolo 56, 51 (2019).
  28. V. Troude and D. Sornette, Unifying framework for amplification mechanisms: Spectral criticality, resonance, and nonnormality, Phys. Rev. Res. 7, L042048 (2025).
  29. S. Särkkä and A. Solin, Applied Stochastic Differential Equations, Institute of Mathematical Statistics Textbooks (Cambridge University, New York, 2019).
  30. S. Chen, E. B. O'Dea, J. M. Drake, and B. I. Epureanu, Eigenvalues of the covariance matrix as early warning signals for critical transitions in ecological systems, Sci. Rep. 9, 2572 (2019).
  31. M. Santos Gutiérrez and V. Lucarini, On some aspects of the response to stochastic and deterministic forcings, J. Phys. A: Math. Theor. 55, 425002 (2022).
  32. M. G. Neubert, T. Klanjscek, and H. Caswell, Reactivity and transient dynamics of predator–prey and food web models, Ecol. Modell. 179, 29 (2004).
  33. N. Santitissadeekorn, G. Froyland, and A. Monahan, Optimally coherent sets in geophysical flows: A transfer-operator approach to delimiting the stratospheric polar vortex, Phys. Rev. E 82, 056311 (2010).
  34. B. F. Farrell and P. J. Ioannou, Perturbation growth and structure in uncertain flows. Part II, J. Atmos. Sci. 59, 2647 (2002).
  35. https://github.com/joshlooks/non-stationary-ews.
  36. T. M. Lenton, V. N. Livina, V. Dakos, E. H. van Nes, and M. Scheffer, Early warning of climate tipping points from critical slowing down: Comparing methods to improve robustness, Philos. Trans. R. Soc. A 370, 1185 (2012).
  37. E. B. O'Dea and J. M. Drake, Disentangling reporting and disease transmission, Theor. Ecol. 12, 89 (2019).
  38. V. R. Saiprasad, V. Troude, and D. Sornette, Inferring non-normal amplification geometry from multivariate time series, arXiv:2607.14786.
  39. D. Papapicco, L. Smith, and G. Donovan, Likelihood estimation of an interpretable early-warning sign of critical transitions, arXiv:2607.05976.
  40. https://doi.org/10.5281/zenodo.18336282.

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