We investigate the long-standing anomaly in the rare decay $B\to K{\mu }^{+}{\mu }^{-}$ within the left-right inverse seesaw (LRIS) model. Global analyses of the $b\to s{\mu }^{+}{\mu }^{-}$ data consistently indicate a significant negative shift in the vector Wilson coefficient, $\mathrm{\Delta }{C}_9^{\mu }\approx -1$, while the axial coefficient $\mathrm{\Delta }{C}_{10}^{\mu }$ remains consistent with zero. We show that a charged-scalar/heavy-neutrino box diagram in the LRIS model naturally generates these values for the Wilson coefficients through a nondecoupling mechanism: the right-handed coupling $Y_{\mu N}^R\propto M_{N_i}/v_R$ produces a contribution to $\mathrm{\Delta }{C}_9^{\mu }$ that is unsuppressed in the heavy-neutrino limit, while the simultaneous presence of a comparable left-handed Dirac Yukawa coupling $Y_{\mu N}^L$ ensures the automatic cancellation $\mathrm{\Delta }{C}_{10}^{\mu }\approx 0$. The potentially dangerous contribution to $B_s-{\overline{B}}_s$ mixing is controlled by the usual Glashow–Iliopoulos–Maiani suppression associated with the top-quark loop, keeping it safely below current experimental bounds throughout the viable parameter space. In addition, a specific right-handed phase texture in the right-handed quark mixing matrix, whose origin can be traced to a discrete $Z_2$ symmetry in the right-handed quark sector, provides a technically natural and radiatively stable structural feature of the model. A numerical scan over the model parameter space identifies a viable region with $y\equiv |Y_{ts,tb}^H|\approx 0.39$ and $M_{H^{\pm }}\gtrsim 600\mathrm{GeV}$, consistent with current flavor and collider experimental constraints.

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• Extensions of gauge sector
• Hadronic decays
• Bottom mesons