In this work, the two-nucleon spectral functions (TNSFs) are defined in terms of the state- and the density-dependent correlation functions in the framework of the lowest-order constrained variational (LOCV) method to calculate the TNSF of the nucleus in the reaction. The Reid soft-core (Reid68) and the potentials are used as the internucleon interactions. Since, the short-range correlation effects are imposed on the wave functions for the individual channels (e.g., the and channels); therefore, the defect wave functions are obtained for various channels such that the high relative momenta () are ignored. The resulting TNSFs for the nucleus are compared with those of the dressed random phase approximation (DRPA) calculations of Geurts et al. and the experimental predictions, especially those of Onderwater et al., (NIKHEF group), where reasonable agreement is found. It is shown that the optimized state-dependent defect wave functions have substantial effects on the TNSF and it is not justified to use the simplified parametrized two-body correlation functions in all of the channels. In agreement with the experimental data of Onderwater et al., the knockout of a pair proton dominates the above reaction cross section. Finally, it is demonstrated that the and peaks, which are expected to be observed in the above reaction cross section, are moved to the lower momenta of out-going protons when the state-dependent correlation functions are imposed.