Transcription of genes can be affected by both biochemical and mechanical factors. Recent experiments suggested that the mechanical stress associated with transcription-induced DNA supercoiling is responsible for the transition from cooperative to antagonistic group dynamics of RNA polymerases (RNAPs) upon promoter repression. To underpin the mechanism behind this drastic transition, we developed a continuum deterministic model for transcription under torsion. In our model, the speed of an RNAP is affected by the local DNA supercoiling, as well as two global factors: (i) the number of RNAPs on the gene affecting the torsional stress experienced by individual RNAPs and (ii) transcription factors blocking the diffusion of DNA supercoils. Our minimal model can successfully reproduce the experimental findings and helps elucidate the interplay of mechanical and biological factors in the collective dynamics of molecular machines involved in gene expression.

We study the effect of a first-order phase transition in a confining $SU(N)$ dark sector with heavy dark quarks. The baryons of this sector are the dark matter candidates. During the confinement phase transition the heavy quarks are trapped inside isolated, contracting pockets of the deconfined phase, giving rise to a second stage of annihilation that dramatically suppresses the dark quark abundance. The surviving abundance is determined by the local accidental asymmetry in each pocket. The correct dark matter abundance is obtained for $\mathcal{O}(1–100)\mathrm{PeV}$ dark quarks, above the usual unitarity bound.

We propose the first explicit holographic duals for a class of superconformal field theories of Argyres-Douglas type, which are inherently strongly coupled and provide a window onto remarkable nonperturbative phenomena (such as mutually nonlocal massless dyons and relevant operators of fractional dimension). The theories under examination are realized by a stack of $M5$-branes wrapped on a sphere with one irregular puncture and one regular puncture. In the dual $11d$ supergravity solutions, the irregular puncture is realized as an internal $M5$-brane source.

We report in situ observations of an electron diffusion region (EDR) and adjacent separatrix region in the Earth’s magnetotail. We observe significant magnetic field oscillations near the lower hybrid frequency which propagate perpendicularly to the reconnection plane. We also find that the strong electron-scale gradients close to the EDR exhibit significant oscillations at a similar frequency. Such oscillations are not expected for a crossing of a steady 2D EDR, and can be explained by a complex motion of the reconnection plane induced by current sheet kinking propagating in the out-of-reconnection-plane direction. Thus, all three spatial dimensions have to be taken into account to explain the observed perturbed EDR crossing. These results shed light on the interplay between magnetic reconnection and current sheet drift instabilities in electron-scale current sheets and highlight the need for adopting a 3D description of the EDR, going beyond the two-dimensional and steady-state conception of reconnection.

We report spatially resolved measurements of static and fluctuating electric fields over conductive (Au) and nonconductive (${\mathrm{SiO}}_2$) surfaces. Using an ultrasensitive “nanoladder” cantilever probe to scan over these surfaces at distances of a few tens of nanometers, we record changes in the probe resonance frequency and damping that we associate with static and fluctuating fields, respectively. We find static and fluctuating fields to be spatially correlated. Furthermore, the fields are of similar magnitude for the two materials. We quantitatively describe the observed effects on the basis of trapped surface charges and dielectric fluctuations in an adsorbate layer. Our results are consistent with organic adsorbates significantly contributing to surface dissipation that affects nanomechanical sensors, trapped ions, superconducting resonators, and color centers in diamond.

Motivated by the possible non-spin-singlet superconductivity in the magic-angle twisted trilayer graphene experiment, we investigate the triplet-pairing superconductivity arising from a correlation-induced spin-fermion model of Dirac fermions with spin, valley, and sublattice degrees of freedom. We find that the $f$-wave pairing is favored due to the valley-sublattice structure, and the superconducting state is time-reversal symmetric, fully gapped, and nontopological. With a small in-plane magnetic field, the superconducting state becomes partially polarized, and the transition temperature can be slightly enhanced. Our results apply qualitatively to Dirac fermions for the triplet-pairing superconductivity in graphene-based moiré systems, which is fundamentally distinct from triplet superconductivity in ${}^3\mathrm{He}$ and ferromagnetic superconductors.

We show that both the classical as well as the quantum definitions of the Fisher information faithfully identify resourceful quantum states in general quantum resource theories, in the sense that they can always distinguish between states with and without a given resource. This shows that all quantum resources confer an advantage in metrology, and establishes the Fisher information as a universal tool to probe the resourcefulness of quantum states. We provide bounds on the extent of this advantage, as well as a simple criterion to test whether different resources are useful for the estimation of unitarily encoded parameters. Finally, we extend the results to show that the Fisher information is also able to identify the dynamical resourcefulness of quantum operations.

We present an instance of a task of minimum-error discrimination of two qubit-qubit quantum channels for which a sequential strategy outperforms any parallel strategy. We then establish two new classes of strategies for channel discrimination that involve indefinite causal order and show that there exists a strict hierarchy among the performance of all four strategies. Our proof technique employs a general method of computer-assisted proofs. We also provide a systematic method for finding pairs of channels that showcase this phenomenon, demonstrating that the hierarchy between strategies is not exclusive to our main example.

The Eastin-Knill theorem states that no quantum error-correcting code can have a universal set of transversal gates. For Calderbank-Shor-Steane codes that can implement Clifford gates transversally, it suffices to provide one additional non-Clifford gate, such as the $T$ gate, to achieve universality. Common methods to implement fault-tolerant $T$ gates, e.g., magic state distillation, generate a significant hardware overhead that will likely prevent their practical usage in the near-term future. Recently, methods have been developed to mitigate the effect of noise in shallow quantum circuits that are not protected by error correction. Error mitigation methods require no additional hardware resources but suffer from a bad asymptotic scaling and apply only to a restricted class of quantum algorithms. In this Letter, we combine both approaches and show how to implement encoded $\text{Clifford}+T$ circuits where Clifford gates are protected from noise by error correction while errors introduced by noisy encoded $T$ gates are mitigated using the quasiprobability method. As a result, $\text{Clifford}+T$ circuits with a number of $T$ gates inversely proportional to the physical noise rate can be implemented on small error-corrected devices without magic state distillation. We argue that such circuits can be out of reach for state-of-the-art classical simulation algorithms.

A standard approach to quantum computing is based on the idea of promoting a classically simulable and fault-tolerant set of operations to a universal set by the addition of “magic” quantum states. In this context, we develop a general framework to discuss the value of the available, nonideal magic resources, relative to those ideally required. We single out a quantity, the quantum-assisted robustness of magic (QROM), which measures the overhead of simulating the ideal resource with the nonideal ones through quasiprobability-based methods. This extends error mitigation techniques, originally developed for noisy intermediate-scale quantum devices, to the case where qubits are logically encoded. The QROM shows how the addition of noisy magic resources allows one to boost classical quasiprobability simulations of a quantum circuit and enables the construction of explicit protocols, interpolating between classical simulation and an ideal quantum computer.

We propose a new field theoretic method for calculating Renyi entropy of a subsystem of many interacting bosons without using replica methods. This method is applicable to dynamics of both open and closed quantum systems starting from arbitrary initial conditions. Our method identifies the Wigner characteristic of a reduced density matrix with the partition function of the whole system with a set of linear sources turned on only in the subsystem, and uses this to calculate the subsystem’s Renyi entropy. We use this method to study the evolution of Renyi entropy in a noninteracting open quantum system starting from an initial Fock state. We find a relation between the initial state and final density matrix which determines whether the entropy shows nonmonotonic behavior in time. For non-Markovian dynamics, we show that the entropy approaches its steady-state value as a power law with exponents governed by nonanalyticities of the bath. We illustrate that this field-theoretic method can be used to study large bosonic open quantum systems.

We study the temporal and vibrational signature of the universal nuclear recoil associated with the electron emission and intramolecular scattering that accompanies the photoelectric effect. We illustrate these phenomena in the photoionization of the CO molecule from the $\mathrm{C}-1s$ orbital using an analytical model that reproduces the entangled character of the nuclear and electronic motion in this process. We show that the photoelectron emission delay can be decomposed into its localization and resonant-confinement components. Photoionization by a broadband x-ray pulse results in a coherent vibrational ionic state delayed compared to the classical sudden-photoemission limit.

We theoretically calculate and experimentally measure the beyond-mean-field (BMF) equation of state in a coherently coupled two-component Bose-Einstein condensate (BEC) in the regime where averaging of the interspecies and intraspecies coupling constants over the hyperfine composition of the single-particle dressed state predicts the exact cancellation of the two-body interaction. We show that with increasing the Rabi-coupling frequency $\mathrm{\Omega }$, the BMF energy density crosses over from the nonanalytic Lee-Huang-Yang scaling $\propto n^{5/2}$ to an expansion in integer powers of density, where, in addition to a two-body BMF term $\propto n^2\sqrt{\mathrm{\Omega }}$, there emerges a repulsive three-body contribution $\propto n^3/\sqrt{\mathrm{\Omega }}$. We experimentally evidence these two contributions, thanks to their different scaling with $\mathrm{\Omega }$, in the expansion of a Rabi-coupled two-component ${}^{39}\mathrm{K}$ condensate in a waveguide. By studying the expansion with and without Rabi coupling, we reveal an important feature relevant for observing BMF effects and associated phenomena in mixtures with spin-asymmetric losses: Rabi coupling helps preserve the spin composition and thus prevents the system from drifting away from the point of the vanishing mean field.

We study the statistical properties of the complex generalization of Wigner time delay ${\tau }_{\mathrm{W}}$ for subunitary wave-chaotic scattering systems. We first demonstrate theoretically that the mean value of the $\mathrm{Re}[{\tau }_W]$ distribution function for a system with uniform absorption strength $\eta$ is equal to the fraction of scattering matrix poles with imaginary parts exceeding $\eta$. The theory is tested experimentally with an ensemble of microwave graphs with either one or two scattering channels and showing broken time-reversal invariance and variable uniform attenuation. The experimental results are in excellent agreement with the developed theory. The tails of the distributions of both real and imaginary time delay are measured and are also found to agree with theory. The results are applicable to any practical realization of a wave-chaotic scattering system in the short-wavelength limit, including quantum wires and dots, acoustic and electromagnetic resonators, and quantum graphs.

$\mathrm{He}\beta$ spectral line shapes are important for diagnosing temperature and density in many dense plasmas. This work presents $\mathrm{He}\beta$ line shapes measured with high spectral resolution from solid-density plasmas with minimized gradients. The line shapes show hallmark features of Stark broadening, including quantifiable redshifts and double-peaked structure with a significant dip between the peaks; these features are compared to models through a Markov chain Monte Carlo framework. Line shape theory using the dipole approximation can fit the width and peak separation of measured line shapes, but it cannot resolve an ambiguity between electron density $n_e$ and ion temperature $T_i$, since both parameters influence the strength of quasistatic ion microfields. Here a line shape model employing a full Coulomb interaction for the electron broadening computes self-consistent line widths and redshifts through the monopole term; redshifts have different dependence on plasma parameters and thus resolve the $n_e-T_i$ ambiguity. The measured line shapes indicate densities that are 80–100% of solid, identifying a regime of highly ionized but well-tamped plasma. This analysis also provides the first strong evidence that dense ions and electrons are not in thermal equilibrium, despite equilibration times much shorter than the duration of x-ray emission; cooler ions may arise from nonclassical thermalization rates or anomalous energy transport. The experimental platform and diagnostic technique constitute a promising new approach for studying ion-electron equilibration in dense plasmas.

We report the transport properties of kagome superconductor ${\mathrm{CsV}}_3{\mathrm{Sb}}_5$ single crystals at magnetic field up to 32 T. The Shubnikov–de Haas oscillations emerge at low temperature and four frequencies of $F_{\alpha }=27\mathrm{T}$, $F_{\beta }=73\mathrm{T}$, $F_{\epsilon }=727\mathrm{T}$, and $F_{\eta }=786\mathrm{T}$ with relatively small cyclotron masses are observed. For $F_{\beta }$ and $F_{\epsilon }$, the Berry phases are close to $\pi$, providing clear evidence of nontrivial topological band structures of ${\mathrm{CsV}}_3{\mathrm{Sb}}_5$. Furthermore, the consistence between theoretical calculations and experimental results implies that these frequencies can be assigned to the Fermi surfaces locating near the boundary of Brillouin zone and confirms that the structure with an inverse Star of David distortion could be the most stable structure at charge density wave state. These results will shed light on the nature of correlated topological physics in kagome material ${\mathrm{CsV}}_3{\mathrm{Sb}}_5$.

We directly measure the low energy excitation modes of the quantum Ising magnet ${\mathrm{LiHoF}}_4$ using microwave spectroscopy. Instead of a single electronic mode, we find a set of collective electronuclear modes, in which the spin-$1/2$ Ising electronic spins hybridize with the bath of spin-$7/2$ Ho nuclear spins. The lowest-lying electronuclear mode softens at the approach to the quantum critical point, even in the presence of disorder. This softening is rapidly quenched by a longitudinal magnetic field. Similar electronuclear structures should exist in other spin-based quantum Ising systems.