HIV-1 protease-substrate complex structure. The substrate residues are red, the predicted protease residues in close interaction with the substrate are blue.

From the article:

Analysis of Correlations between Energy and Residue Fluctuations in Native Proteins and Determination of Specific Sites for Binding
Turkan Haliloglu and Burak Erman
Phys. Rev. Lett. 102, 088103 (2009)

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