Neuromodulatory levels in the brain change moment to moment, yet are typically ignored in studies of neural criticality, where empirical support remains varied. Here we show in a biophysical network of bursting neurons that arousal acts as a mechanistic control parameter for a directed percolation phase transition. At intermediate arousal, neuronal activity exhibits peaked susceptibility, power-law avalanche size and duration distributions, universal shape collapse, and anomalous diffusion, jointly satisfying the hyperscaling relation of the 2+1-dimensional directed percolation universality class. Reanalyzing extracellular recordings in awake mice, we find that time-resolved susceptibility tracks pupil-inferred arousal as the model predicts. These results identify arousal as a physiological control parameter for neural criticality, offering a statistical-physics basis for the Yerkes-Dodson effect, and imply that arousal should be tracked at fine temporal resolution to obtain reliable empirical estimates of neural criticality.

Close

PrevNext

View figure in article

• Directed percolation
• Mechanisms of phase transition regulation & control in biology
• Neuronal avalanches
• Neuronal dynamics
• Scaling laws of complex systems