- Open Access
Different behaviors of diffusing diffusivity dynamics based on three different definitions of fractional Brownian motion
Phys. Rev. E 112, 014108 – Published 7 July, 2025
DOI: https://doi.org/10.1103/w8gv-3fxt
Abstract
The effects of "diffusing diffusivity” (DD), a stochastically time-varying diffusion coefficient, are explored within the frameworks of three different forms of fractional Brownian motion (FBM): (i) the Langevin equation driven by fractional Gaussian noise (LE-FBM), (ii) the Weyl integral representation introduced by Mandelbrot and van Ness (MN-FBM), and (iii) the Riemann-Liouville fractional integral representation (RL-FBM) introduced by Lévy. The statistical properties of the three FBM-generalized DD models are examined, including the mean-squared displacement (MSD), mean-squared increment (MSI), autocovariance function (ACVF) of increments, and the probability density function (PDF). Despite the long-believed equivalence of MN-FBM and LE-FBM, their corresponding FBM-DD models exhibit distinct behavior in terms of MSD and MSI. In the MN-FBM-DD model, the statistical characteristics directly reflect an effective diffusivity equal to its mean value. In contrast, in LE-FBM-DD, correlations in the random diffusivity give rise to an unexpected crossover behavior in both MSD and MSI. We also find that the MSI and ACVF are nonstationary in RL-FBM-DD but stationary in the other two DD models. All DD models display a crossover from a short-time non-Gaussian PDF to a long-time Gaussian PDF. Our findings offer guidance for experimentalists in selecting appropriate FBM-generalized models to describe viscoelastic yet non-Gaussian dynamics in bio- and soft-matter systems with heterogeneous environments.
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References (118)
- R. Brown, A brief account of microscopical observations made in the months of June, July and August 1827, on the particles contained in the pollen of plants; and on the general existence of active molecules in organic and inorganic bodies, Philos. Mag. 4, 161 (1828).
- A. Einstein, Über die von der molekularkinetischen Theorie der Wärme geforderte Bewegung von in ruhenden Flüssigkeiten suspendierten Teilchen, Ann. Phys. 322, 549 (1905).
- W. Sutherland, A dynamical theory of diffusion for nonelectrolytes and the molecular mass of albumin, Philos. Mag. 9, 781 (1905).
- M. von Smoluchowski, Zur kinetischen Theorie der Brownschen Molekularbewegung und der Suspensionen, Ann. Phys. 326, 756 (1906).
- P. Langevin, Sur la théorie du mouvement brownien, C. R. Acad. Sci. (Paris) 146, 530 (1908).
- J. Perrin, Les atomes (Félix Alcan, Paris, 1913); English version: J. Perrin and D. L. Hammick (translator), Atoms (Kessinger Publishing, Whitefish, MT).
- R. Metzler, J.-H. Jeon, A. Cherstvy, and E. Barkai, Anomalous diffusion models and their properties: non-stationarity, non-ergodicity, and ageing at the centenary of single particle tracking, Phys. Chem. Chem. Phys. 16, 24128 (2014).
- M. Weiss, M. Elsner, F. Kartberg, and T. Nilsson, Anomalous subdiffusion is a measure for cytoplasmic crowding in living cells, Biophys. J. 87, 3518 (2004).
- I. Golding and E. C. Cox, Physical nature of bacterial cytoplasm, Phys. Rev. Lett. 96, 098102 (2006).
- J.-H. Jeon, V. Tejedor, S. Burov, E. Barkai, C. Selhuber-Unkel, K. Berg-Sørensen, L. Oddershede, and R. Metzler, In vivo anomalous diffusion and weak ergodicity breaking of lipid granules, Phys. Rev. Lett. 106, 048103 (2011).
- R. Großmann, L. S. Bort, T. Moldenhawer, M. Stange, S. S. Panah, R. Metzler, and C. Beta, Non-Gaussian displacements in active transport on a carpet of motile cells, Phys. Rev. Lett. 132, 088301 (2024).
- J.-H. Jeon, M. Javanainen, H. Martinez-Seara, R. Metzler, and I. Vattulainen, Protein crowding in lipid bilayers gives rise to non-Gaussian anomalous lateral diffusion of phospholipids and proteins, Phys. Rev. X 6, 021006 (2016).
- A. Godec, M. Bauer, and R. Metzler, Collective dynamics effect transient subdiffusion of inert tracers in flexible gel networks, New J. Phys. 16, 092002 (2014).
- T. Akimoto, E. Yamamoto, K. Yasuoka, Y. Hirano, and M. Yasui, Non-Gaussian fluctuations resulting from power-law trapping in a lipid bilayer, Phys. Rev. Lett. 107, 178103 (2011).
- F. Michael and M. D. Johnson, Financial market dynamics, Physica A 320, 525 (2003).
- R. N. Mantegna and H. E. Stanley, An Introduction to Econophysics: Correlations and Complexity in Finance (Cambridge University Press, Cambridge, 2000).
- N. E. Humphries et al., Environmental context explains Lévy and Brownian movement patterns of marine predators, Nature (London) 465, 1066 (2010).
- P. G. Meyer, A. G. Cherstvy, H. Seckler, R. Hering, N. Blaum, F. Jeltsch, and R. Metzler, Directedness, correlations, and daily cycles in springbok motion: from data via stochastic models to movement prediction, Phys. Rev. Res. 5, 043129 (2023).
- O. Vilk, Y. Orchan, M. Charter, N. Ganot, S. Toledo, R. Nathan, and M. Assaf, Ergodicity breaking in area-restricted search of Avian predators, Phys. Rev. X 12, 031005 (2022).
- O. Vilk et al., Unravelling the origins of anomalous diffusion: From molecules to migrating storks, Phys. Rev. Res. 4, 033055 (2022).
- A. Lazarian and H. Yan, Superdiffusion of cosmic rays: implications for cosmic ray acceleration, Astrophys. J. 784, 38 (2014).
- B. Berkowitz, A. Cortis, M. Dentz, and H. Scher, Modeling non-Fickian transport in geological formations as a continuous time random walk, Rev. Geophys. 44, 2005RG000178 (2006).
- A. Rajyaguru, R. Metzler, I. Dror, D. Grolimund, and B. Berkowitz, Diffusion in porous rock is anomalous, Environ. Sci. Technol. 58, 8946 (2024).
- D. Wei, A. Rubio-Abadal, B. Ye, F. Machado, J. Kemp, K. Srakaew, S. Hollerith, J. Rui, S. Gopalakrishnan, N. Y. Yao, I. Bloch, and J. Zeiher, Quantum gas microscopy of Kardar-Parisi-Zhang superdiffusion, Science 376, 716 (2022).
- J.-P. Bouchaud and A. Georges, Anomalous diffusion in disordered media: Statistical mechanisms, models and physical applications, Phys. Rep. 195, 127 (1990).
- I. M. Sokolov, Models of anomalous diffusion in crowded environments, Soft Matter 8, 9043 (2012).
- E. Barkai, Y. Garini, and R. Metzler, Strange kinetics of single molecules in living cells, Phys. Today 65(8), 29 (2012).
- Y. Mishura, Stochastic Calculus for Fractional Brownian Motion and Related Processes (Springer, Berlin, 2008).
- M. M. Meerschaert and A. Sikorskii, Stochastic Models for Fractional Calculus, Vol. 43 (Walter de Gruyter, Berlin, 2019).
- E. W. Montroll and G. H. Weiss, Random walks on lattices. II, J. Math. Phys. 6, 167 (1965).
- J. Klafter, A. Blumen, and M. F. Shlesinger, Stochastic pathway to anomalous diffusion, Phys. Rev. A 35, 3081 (1987).
- B. D. Hughes, Random Walks and Random Environments, Vol. 1: Random walks (Oxford University Press, Oxford, UK, 1995).
- R. Metzler and J. Klafter, The random walk's guide to anomalous diffusion: a fractional dynamics approach, Phys. Rep. 339, 1 (2000).
- J. M. Berger and B. Mandelbrot, A new model for error clustering in telephone circuits, IBM J. Res. Develop. 7, 224 (1963).
- H. Scher and E. W. Montroll, Anomaous transit-time dispersion in amorphous solids, Phys. Rev. B 12, 2455 (1975).
- A. N. Kolmogorov, Wienersche Spiralen und einige andere interessante Kurven im Hilbertschen Raum, C. R. (Doklady) Acad. Sci. URSS (N. S.) 26, 115 (1940).
- B. B. Mandelbrot and J. W. van Ness, Fractional Brownian motions, fractional noises and applications, SIAM Rev. 10, 422 (1968).
- G. Guigas, V. Kalla, and M. Weiss, Probing the nanoscale viscoelasticity of intracellular fluids in living cells, Biophys. J. 93, 316 (2007).
- S. C. Weber, A. J. Spakowitz, and J. A. Theriot, Bacterial chromosomal loci move subdiffusively through a viscoelastic cytoplasm, Phys. Rev. Lett. 104, 238102 (2010).
- S. Janušonis, N. Detering, R. Metzler, and T. Vojta, Serotonergic axons as fractional brownian motion paths: insights into the self-organization of regional densities, Front. Comput. Neurosci. 14, 56 (2020).
- S. Janušonis, J. H. Haiman, R. Metzler, and T. Vojta, Predicting the distribution of serotonergic axons: a supercomputing simulation of reflected fractional Brownian motion in a 3D-mouse brain model, Front. Comput. Neurosci. 17, 1189853 (2023).
- J. Gatheral, T. Jaisson, and M. Rosenbaum, Volatility is rough, Quant. Financ. 18, 933 (2018).
- T. Guggenberger, G. Pagnini, T. Vojta, and R. Metzler, Fractional Brownian motion in a finite interval: correlation effects depletion or accretion zones of particles near boundaries, New J. Phys. 21, 022002 (2019).
- A. H. O. Wada and T. Vojta, Fractional Brownian motion with a reflecting wall, Phys. Rev. E 97, 020102(R) (2018).
- T. Vojta, S. Halladay, S. Skinner, S. Janušonis, T. Guggenberger, and R. Metzler, Reflected fractional Brownian motion in one and higher dimensions, Phys. Rev. E 102, 032108 (2020).
- T. Guggenberger, A. Chechkin, and R. Metzler, Fractional Brownian motion in superharmonic potentials and non-Boltzmann stationary distributions, J. Phys. A 54, 29LT01 (2021).
- T. Guggenberger, A. V. Chechkin, and R. Metzler, Absence of confinement and non-Boltzmann stationary states of fractional Brownian motion in shallow external potentials, New J. Phys. 24, 073006 (2022).
- A. Pacheco-Pozo and D. Krapf, Fractional Brownian motion with fluctuating diffusivities, Phys. Rev. E 110, 014105 (2024).
- W. Wang, M. Balcerek, K. Burnecki, A. Chechkin, S. Janušonis, J. Ślęzak, T. Vojta, A. Wyłomańska, and R. Metzler, Memory-multi-fractional Brownian motion with continuous correlations, Phys. Rev. Res. 5, L032025 (2023).
- M. Balcerek, A. Wyłomańska, K. Burnecki, R. Metzler, and D. Krapf, Modelling intermittent anomalous diffusion with switching fractional Brownian motion, New J. Phys. 25, 103031 (2023).
- J. Ślęzak and R. Metzler, Minimal model of diffusion with time changing Hurst exponent, J. Phys. A 56, 35LT01 (2023).
- T. A. Waigh and N. Korabel, Heterogeneous anomalous transport in cellular and molecular biology, Rep. Prog. Phys. 86, 126601 (2023).
- B. Wang, J. Kuo, S. C. Bae, and S. Granick, When Brownian diffusion is not Gaussian, Nat. Mater. 11, 481 (2012).
- B. Wang, S. M. Anthony, S. C. Bae, and S. Granick, Anomalous yet Brownian, Proc. Natl. Acad. Sci. USA 106, 15160 (2009).
- J. M. Miotto, S. Pigolotti, A. V. Chechkin, and S. Roldán-Vargas, Length scales in Brownian yet non-Gaussian dynamics, Phys. Rev. X 11, 031002 (2021).
- A. Alexandre, M. Lavaud, N. Fares, E. Millan, Y. Louyer, T. Salez, Y. Amarouchene, T. Guérin, and D. S. Dean, Non-Gaussian diffusion near surfaces, Phys. Rev. Lett. 130, 077101 (2023).
- F. Rusciano, R. Pastore, and F. Greco, Fickian Non-Gaussian diffusion in glass-forming liquids, Phys. Rev. Lett. 128, 168001 (2022).
- I. Chakraborty and Y. Roichman, Disorder-induced Fickian yet non-Gaussian diffusion in heterogeneous media, Phys. Rev. Res. 2, 022020(R) (2020).
- S. Nampoothiri, E. Orlandini, F. Seno, and F. Baldovin, Brownian non-Gaussian polymer diffusion and queuing theory in the mean-field limit, New J. Phys. 24, 023003 (2022).
- M. V. Chubynsky and G. W. Slater, Diffusing diffusivity: A model for anomalous, yet Brownian, diffusion, Phys. Rev. Lett. 113, 098302 (2014).
- A. V. Chechkin, F. Seno, R. Metzler, and I. M. Sokolov, Brownian yet non-Gaussian diffusion: From superstatistics to subordination of diffusing diffusivities, Phys. Rev. X 7, 021002 (2017).
- V. Sposini, A. V. Chechkin, F. Seno, G. Pagnini, and R. Metzler, Random diffusivity from stochastic equations: comparison of two models for Brownian yet non-Gaussian diffusion, New J. Phys. 20, 043044 (2018).
- V. Sposini, D. S. Grebenkov, R. Metzler, G. Oshanin, and F. Seno, Universal spectral features of different classes of random diffusivity processes, New J. Phys. 22, 063056 (2020).
- N. Tyagi and B. J. Cherayil, Non-Gaussian Brownian diffusion in dynamically disordered thermal environments, J. Phys. Chem. B 121, 7204 (2017).
- R. Jain and K. L. Sebastian, Lévy flight with absorption: A model for diffusing diffusivity with long tails, Phys. Rev. E 95, 032135 (2017).
- R. Jain and K. L. Sebastian, Diffusion in a crowded, rearranging environment, J. Phys. Chem. B 120, 3988 (2016).
- T. J. Lampo, S. Stylianidou, M. P. Backlund, P. A. Wiggins, and A. J. Spakowitz, Cytoplasmic RNA-protein particles exhibit non-Gaussian subdiffusive behavior, Biophys. J. 112, 532 (2017).
- W. He, H. Song, Y. Su, L. Geng, B. J. Ackerson, H. B. Peng, and P. Tong, Dynamic heterogeneity and non-Gaussian statistics for acetylcholine receptors on live cell membrane, Nat. Commun. 7, 11701 (2016).
- S. Thapa, N. Lukat, C. Selhuber-Unkel, A. G. Cherstvy, and R. Metzler, Transient superdiffusion of polydisperse vacuoles in highly motile amoeboid cells, J. Chem. Phys. 150, 144901 (2019).
- A. G. Cherstvy, O. Nagel, C. Beta, and R. Metzler, Non-Gaussianity, population heterogeneity, and transient superdiffusion in the spreading dynamics of amoeboid cells, Phys. Chem. Chem. Phys. 20, 23034 (2018).
- A. Díez Fernández, P. Charchar, A. G. Cherstvy, R. Metzler, and M. W. Finnis, The diffusion of doxorubicin drug molecules in silica nanochannels is non-Gaussian and intermittent, Phys. Chem. Chem. Phys. 22, 27955 (2020).
- W. Wang, F. Seno, I. M. Sokolov, A. V. Chechkin, and R. Metzler, Unexpected crossovers in correlated random-diffusivity processes, New J. Phys. 22, 083041 (2020).
- W. Wang, A. G. Cherstvy, A. V. Chechkin, S. Thapa, F. Seno, X. Liu, and R. Metzler, Fractional Brownian motion with random diffusivity: emerging residual nonergodicity below the correlation time, J. Phys. A: Math. Theor. 53, 474001 (2020).
- L. Luo and M. Yi, Non-Gaussian diffusion in static disordered media, Phys. Rev. E 97, 042122 (2018).
- L. Luo and M. Yi, Quenched trap model on the extreme landscape: The rise of subdiffusion and non-Gaussian diffusion, Phys. Rev. E 100, 042136 (2019).
- S. Park, X. Durang, R. Metzler, and J.-H. Jeon, Fickian yet non-Gaussian diffusion in an annealed heterogeneous environment, arXiv:2503.15366.
- Q. Wei, W. Wang, Y. Tang, R. Metzler, and A. Chechkin, Fractional Langevin equation far from equilibrium: Riemann-Liouville fractional Brownian motion, spurious nonergodicity, and aging, Phys. Rev. E 111, 014128 (2025).
- A. N. Kolmogorov, The local structure of turbulence in incompressible viscous fluid for very large Reynolds numbers, Dokl. Akad. Nauk. SSSR 30, 301 (1941).
- A. N. Kolmogorov, Dissipation of energy in locally isotropic turbulence, Dokl. Akad. Nauk. SSSR 32, 19 (1941).
- A. M. Yaglom, and M. S. Pinsker, Random process with stationary increments of order , Dokl. Akad. Nauk. SSSR 90, 731 (1953).
- A. M. Yaglom, Correlation Theory of Stationary and Related Random Functions, Vol. 1, Basic Results, Vol. 2, Supplementary Notes and References (Springer, New York, 1987).
- D. Marinucci and P. M. Robinson, Alternative forms of fractional Brownian motion, J. Statist. Plan. Infer. 80, 111 (1999).
- M. Balcerek, K. Burnecki, S. Thapa, A. Wyłomańska, and A. V. Chechkin, Fractional Brownian motion with random Hurst exponent: Accelerating diffusion and persistence transitions, Chaos 32, 093114 (2022).
- D. Molina-Garcia, T. Sandev, H. Safdari, G. Pagnini, A. Chechkin, and R. Metzler, Crossover from anomalous to normal diffusion: truncated power-law noise correlations and applications to dynamics in lipid bilayers, New J. Phys. 20, 103027 (2018).
- P. Lévy, in Random Functions: General Theory with Special Reference to Laplacian Random Functions (University of California Press, Berkeley, 1953).
- S. C. Lim, Fractional Brownian motion and multifractional Brownian motion of Riemann-Liouville type, J. Phys. A: Math. Theor. 34, 1301 (2001).
- D. T. Gillespie, Exact numerical simulation of the Ornstein-Uhlenbeck process and its integral, Phys. Rev. E 54, 2084 (1996).
- D. T. Gillespie, The mathematics of Brownian motion and Johnson noise, Am. J. Phys. 64, 225 (1996).
- J. R. M. Hosking, Modeling persistence in hydrological time series using fractional differencing, Water Resour. Res. 20, 1898 (1984).
- D. Dieker, Simulation of fractional Brownian motion, Master's thesis, University of Twente, The Netherlands, 2004.
- J. F. Coeurjolly, Inférence statistique pour les mouvements browniens fractionnaires et multifractionnaires, Ph.D. thesis, Université Joseph-Fourier-Grenoble I, France, 2000.
- A. T. Wood and G. Chan, Simulation of stationary Gaussian processes in , J. Comput. Graph. Stat. 3, 409 (1994).
- S. Rambaldi and O. Oinazza, An accurate fractional Brownian motion generator, Physica A 208, 21 (1994).
- C. Beck and E. G. D. Cohen, Superstatistics, Physica A 322, 267 (2003).
- M. Weiss, Single-particle tracking data reveal anticorrelated fractional Brownian motion in crowded fluids, Phys. Rev. E 88, 010101 (2013).
- A. V. Weigel, B. Simon, M. M. Tamkun, and D. Krapf, Ergodic and nonergodic processes coexist in the plasma membrane as observed by single-molecule tracking, Proc. Natl. Acad. Sci. 108, 6438 (2011).
- G. Sikora, K. Burnecki, and A. Wyłomańska, Mean-squared-displacement statistical test for fractional Brownian motion, Phys. Rev. E 95, 032110 (2017).
- C. L. Vestergaard, P. C. Blainey, and H. Flyvbjerg, Optimal estimation of diffusion coefficients from single-particle trajectories, Phys. Rev. E 89, 022726 (2014).
- A. Robson, K. Burrage, and M. C. Leake Inferring diffusion in single live cells at the single-molecule level, Phil. Trans. R. Soc. B 368, 20120029 (2013).
- J. Krog, L. H. Jacobsen, F. W. Lund, D. Wüstner, and M. A. Lomholt, Bayesian model selection with fractional Brownian motion, J. Stat. Mech. (2018) 093501.
- S. Thapa, M. A. Lomholt, J. Krog, A. G. Cherstvy, and R. Metzler, Bayesian analysis of single-particle tracking data using the nested-sampling algorithm: maximum-likelihood model selection applied to stochastic-diffusivity data, Phys. Chem. Chem. Phys. 20, 29018 (2018).
- G. Muñoz-Gil, M. A. Garcia-March, C. Manzo, J. D. Martín-Guerrero, and M. Lewenstein, Single trajectory characterization via machine learning, New J. Phys. 22, 013010 (2020).
- H. Seckler, J. Szwabiński, and R. Metzler, Machine-learning solutions for the analysis of single-particle diffusion trajectories, J. Phys. Chem. Lett. 14, 7910 (2023).
- C. Manzo, Extreme learning machine for the characterization of anomalous diffusion from single trajectories (AnDi-ELM), J. Phys. A: Math. Theor. 54, 334002 (2021).
- H. Seckler and R. Metzler, Bayesian deep learning for error estimation in the analysis of anomalous diffusion, Nat. Commun. 13, 6717 (2022).
- P. Kowalek, H. Loch-Olszewska, and J. Szwabiński, Classification of diffusion modes in single-particle tracking data: Feature-based versus deep-learning approach, Phys. Rev. E 100, 032410 (2019).
- G. Muñoz-Gil et al., Objective comparison of methods to decode anomalous diffusion, Nat. Commun. 12, 6253 (2021).
- N. Granik, L. E. Weiss, E. Nehme, M. Levin, M. Chein, E. Perlson, Y. Roichman, and Y. Shechtman, Single-particle diffusion characterization by deep learning, Biophys. J. 117, 185 (2019).
- D. Han, N. Korabel, R. Chen, M. Johnston, A. Gavrilova, V. J. Allan, S. Fedotov, and T. A. Waigh, Deciphering anomalous heterogeneous intracellular transport with neural networks, eLife 9, e52224 (2020).
- M. Balcerek, A. Pacheco-Pozo, A. Wyłomańska, and D. Krapf, Evaluating Gaussianity of heterogeneous fractional Brownian motion, arXiv:2501.10472.
- Y. Lanoiselée, A. Stanislavsky, D. Calebiro, and A. Weron, Temperature and friction fluctuations inside a harmonic potential, Phys. Rev. E 106, 064127 (2022).
- V. Sposini, S. Nampoothiri, A. Chechkin, E. Orlandini, F. Seno, and F. Baldovin, Being heterogeneous is disadvantageous: Brownian non-Gaussian searches, Phys. Rev. E 109, 034120 (2024).
- V. Sposini, S. Nampoothiri, A. Chechkin, E. Orlandini, F. Seno, and F. Baldovin, Being heterogeneous is advantageous: extreme Brownian non-Gaussian searches, Phys. Rev. Lett. 132, 117101 (2024).
- M. R. Evans and S. N. Majumdar, Diffusion with stochastic resetting, Phys. Rev. Lett. 106, 160601 (2011).
- A. Pal and S. Reuveni, First passage under restart, Phys. Rev. Lett. 118, 030603 (2017).
- A. L. Stella, A. Chechkin, and G. Teza, Anomalous dynamical scaling determines universal critical singularities, Phys. Rev. Lett. 130, 207104 (2023).
- A. L. Stella, A. Chechkin, and G. Teza, Universal singularities of anomalous diffusion in the Richardson class, Phys. Rev. E 107, 054118 (2023).
- https://github.com/WeiWangNuaa/FBM-DD-model.