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    Distribution of singular values in large sample cross-covariance matrices

    Arabind Swain

    Sean Alexander Ridout

    Ilya Nemenman

    • Department of Physics, Emory University, Atlanta, Georgia 30322, USA and Initiative in Theory and Modeling of Living Systems, Atlanta, Georgia 30322, USA

    • Department of Physics, Emory University, Atlanta, Georgia 30322, USA; Department of Biology, Emory University, Atlanta, Georgia 30322, USA; and Initiative in Theory and Modeling of Living Systems, Atlanta, Georgia 30322, USA

    Phys. Rev. E 112, 035312 – Published 15 September, 2025

    DOI: https://doi.org/10.1103/nb6f-4b6p

    Abstract

    For two high-dimensional datasets X and Y, with dimensionalities NX and NY of order of the number of samples T, estimates of their cross-covariance will have large fluctuations. These sampling fluctuations can be studied by analyzing the case of uncorrelated X and Y, samples of which comprise large matrices X and Y with Gaussian i.i.d. entries and dimensions T×NX and T×NY, respectively. For this problem, we derive the probability distribution of the singular values of X⊤Y in different parameter regimes. This extends the Marchenko–Pastur result for the distribution of eigenvalues of empirical sample covariance matrices to singular values of empirical cross-covariances. We analyze these results in a variety of limits, arguing that in many cases signals may be detected even if one or both datasets are of dimensionality greater than the number of samples, where methods based on whitening of the cross-covariance cannot be used. Our results will help to establish statistical significance of cross-correlations in many data-science applications.

    Physics Subject Headings (PhySH)

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    This article appears in the following collection:

    Statistical Physics Meets Machine Learning - Machine Learning Meets Statistical Physics

    The Editors of Physical Review E are pleased to present the Collection on Statistical Physics Meets Machine Learning - Machine Learning Meets Statistical Physics, highlighting research at the intersection of machine learning and statistical physics, on the occasion of the two Statistical Physics Meets Machine Learning and the two Machine Learning Meets Statistical Physics sessions at the 2025 Global Physics Summit. The Collection is being guest edited by David Schwab (CUNY, New York) and Yuhai Tu (IBM Watson Research Center Yorktown Heights, NY). Every article published in this collection underwent a rigorous peer review process, adhering to the same high standards applied to all papers. The Physical Review E editorial team managed the peer review and made all editorial decisions.

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