Processes controlled by stochastic synthesis and degradation (SSD) are widespread in biology but their reaction kinetics are not well understood. Using methods borrowed from the theory of resetting processes, we determine the first-passage properties of a collection of independent particles that are synthesized and degraded at constant rates, and follow an arbitrary diffusive motion. At equal synthesis and degradation rates, the mean reaction time with a target site can be minimized as in stochastic resetting, and a $CV$ criterion is derived. When the degradation rate is held fixed and the synthesis costs are taken into account, an optimal synthesis rate is obtained. In bounded domains, despite particle degradation, SSD improves the mean search time compared to a single nondegrading particle if the synthesis rate exceeds a critical value which obeys a universal relation. We illustrate these findings with Brownian diffusion on the infinite line and in an interval.

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• Diffusion
• Stochastic resetting
• Biomolecules
• First passage problems