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Interplay between morphology and competition in two-dimensional colony expansion

Daniel W. Swartz, Hyunseok Lee, and Mehran Kardar

Kirill S. Korolev

  • Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA

  • Department of Physics, Graduate Program in Bioinformatics and Biological Design Center, Boston University, Boston, Massachusetts 02215, USA

Phys. Rev. E 108, L032301 – Published 8 September, 2023

DOI: https://doi.org/10.1103/PhysRevE.108.L032301

Abstract

In growing populations, the fate of mutations depends on their competitive ability against the ancestor and their ability to colonize new territory. Here we present a theory that integrates both aspects of mutant fitness by coupling the classic description of one-dimensional competition (Fisher equation) to the minimal model of front shape (Kardar-Parisi-Zhang equation). We solve these equations and find three regimes, which are controlled solely by the expansion rates, solely by the competitive abilities, or by both. Collectively, our results provide a simple framework to study spatial competition.

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