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In silico testing of the universality of epithelial tissue growth

Mahmood Mazarei1, Jan Åström2, Jan Westerholm3, and Mikko Karttunen1,4

  • 1Department of Physics and Astronomy, Western University, 1151 Richmond Street, London, Ontario, Canada N6A 3K7
  • 2CSC Scientific Computing Limited, Kägelstranden 14, FI-02150 Esbo, Finland
  • 3Faculty of Science and Engineering, Åbo Akademi University, Vattenborgsvägen 3, FI-20500 Åbo, Finland
  • 4Department of Chemistry, Western University, 1151 Richmond Street, London, Ontario, Canada N6A 5B7

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Phys. Rev. E 106, L062402 – Published 12 December, 2022

DOI: https://doi.org/10.1103/PhysRevE.106.L062402

Abstract

The universality of interfacial roughness in growing epithelial tissue has remained a controversial issue. Kardar-Parisi-Zhang (KPZ) and molecular beam epitaxy (MBE) universality classes have been reported among other behaviors including a total lack of universality. Here, we simulate tissues using the cellsim3d kinetic division model for deformable cells to investigate cell-colony scaling. With seemingly minor model changes, it can reproduce both KPZ- and MBE-like scaling in configurations that mimic the respective experiments. Tissue growth with strong cell-cell adhesion in a linear geometry is KPZ like, while weakly adhesive tissues in a radial geometry are MBE like. This result neutralizes the apparent scaling controversy.

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Phys. Rev. E 106, L062402– Published 12 December, 2022
  • Received 29 March 2022
  • Accepted 22 November 2022
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