The thermodynamic uncertainty relation (TUR) provides a stricter bound for entropy production (EP) than that of the thermodynamic second law. This stricter bound can be utilized to infer the EP and derive other tradeoff relations. Though the validity of the TUR has been verified in various stochastic systems, its application to general Langevin dynamics has not been successfully unified, especially for underdamped Langevin dynamics, where odd parity variables in time-reversal operation such as velocity get involved. Previous TURs for underdamped Langevin dynamics are neither experimentally accessible nor reduced to the original form of the overdamped Langevin dynamics in the zero-mass limit. Here, we find a TUR for underdamped Langevin dynamics with an arbitrary time-dependent protocol, which is operationally accessible when all mechanical forces are controllable. We show that the original TUR is a consequence of our underdamped TUR in the zero-mass limit. This indicates that the TUR formulation presented here can be regarded as the universal form of the TUR for general Langevin dynamics.

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• Entropy production
• Nonequilibrium & irreversible thermodynamics
• Stochastic processes