A novel inequality involving the residual information and genuine multi-entropy was proposed in for tripartite holographic pure states, using which it was argued, that purely GHZ-like tripartite entanglement is not allowed in holography. In this work, we generalize this holographic signal inequality to mixed states. In a minimal extension, we compute the reflected genuine multi-entropy following and find a class of holographic geometries that violate this minimally extended inequality due to a vanishing Markov gap. We can symmetrize this prescription, where instead of computing the residual information on the given mixed state ${\rho }_{ABC}$, we compute it on its canonical purification. The inequality is restored on the canonically purified state. Finally, we conjecture a new inequality for tripartite holographic states and give supporting evidence.