We present a new hadronic EoS with hyperons built within the relativistic mean-field (RMF) formalism with baryon-density- and isospin-density-dependent couplings. Motivated by microscopic calculations showing density- and isospin-asymmetry-dependence of self-energies, we implement a new form for the baryon-meson couplings. The parameters for the couplings are constrained by a Bayesian analysis, which anchors the model to nuclear saturation properties, chiral effective field theory ($\chi \mathrm{EFT}$) predictions for pure neutron matter, heavy-ion collision data, and HALQCD-based hyperon potential calculations at 3-momentum $|\mathbf{k}|=0$ in both isospin-symmetric and pure neutron matter. The resulting EoS satisfies neutron star mass-radius constraints from NICER and GW170817, providing another way to address the hyperon puzzle. The low-density part of the EoS is described via nuclear statistical equilibrium with modern mass tables (AME20/FRDM12, 8244 nuclei), providing a novel and complete general-purpose EoS for astrophysical simulations.

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• Nuclear matter in neutron stars