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    Statistical mechanics for networks of real neurons

    Leenoy Meshulam* and William Bialek

    Leenoy Meshulam*

    • Department of Physics, Department of Neuroscience, and Carney Institute for Brain Science, Brown University, Providence, Rhode Island 02912, USAand Center for Computational Neuroscience,University of Washington, Seattle, Washington 98195, USA

    William Bialek

    • Joseph Henry Laboratories of Physics and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA

    • *leenoy@brown.edu
    • wbialek@princeton.edu

    Rev. Mod. Phys. 97, 045002 – Published 6 November, 2025

    DOI: https://doi.org/10.1103/jcrn-3nrc

    Abstract

    Perceptions and actions, thoughts and memories result from coordinated activity in hundreds or even thousands of neurons in the brain. It is an old dream of the physics community to provide a statistical mechanics description for these and other emergent phenomena of life. These aspirations appear in a new light because of developments in our ability to measure the electrical activity of the brain, sampling thousands of individual neurons simultaneously over hours or days. The progress that has been made in bringing theory and experiment together is reviewed, with a focus on maximum entropy methods and a phenomenological renormalization group. These approaches have uncovered new, quantitatively reproducible collective behaviors in networks of real neurons and provide examples of rich parameter-free predictions that agree in detail with experiments.

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