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Phys. Rev. E (1)

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How the Immune System Learns

Arup K. Chakraborty ^1,2,3,4,5,*, Anupama Jayaraman ^1,4, and Daniel P. Newton ^4,6

¹Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
²Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
³Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
⁴Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
⁵Ragon Institute of Massachusetts General Brigham, Massachusetts Institute of Technology & Harvard University, Cambridge, Massachusetts 02139, USA
⁶Department of Physics, Harvard University, Cambridge, Massachusetts 02138, USA

^*Contact author: arupc@mit.edu

Perspective on physical systems with a purpose: Using tunable degrees of freedom to enable function

M. Lisa Manning

Phys. Rev. E 114 041004 (2026)

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