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Optimal Treatment for Drug-Induced Cancer Persisters Involves Release Periods and Intermediate Drug Doses

Mattia Corigliano1,*, Arianna Di Bernardo2, Marco Cosentino Lagomarsino1,2,3,†, and Simone Pompei1,†

  • 1IFOM-ETS, The AIRC Institute of Molecular Oncology, via Adamello 16, 20139 Milan, Italy
  • 2Dipartimento di Fisica, Università degli studi di Milano, via Celoria 16, 20133, Milan, Italy
  • 3Istituto Nazionale di Fisica Nucleare, Sezione di Milano, via Celoria 16, 20133, Milan, Italy

  • *Contact author: mattia.corigliano@ifom.eu
  • †These authors jointly supervised this work: marco.cosentino-lagomarsino@ifom.eu, simone.pompei@ifom.eu

Parrondo-like evolutionary advantage from stochastic switching between specialist and generalist strategies in fluctuating environments

De-Ming Liu, Zhi-Xi Wu, and Jian-Yue Guan

Phys. Rev. E 113 024312 (2026)

Optimal dosing of anti-cancer treatment under drug-induced plasticity

Einar Bjarki Gunnarsson, Benedikt Vilji Magnússon, and Jasmine Foo

npj Syst Biol Appl 11 98 (2025)

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