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Data-Driven Discovery of Biophysical T Cell Receptor Cospecificity Rules

Andrew G. T. Pyo¹, Yuta Nagano ^2,3, Martina Milighetti ^2,4, James Henderson ^2,5, Curtis G. Callan, Jr.^1,6, Benny Chain^2,7, Ned S. Wingreen ^8,9, and Andreas Tiffeau-Mayer ^2,5

¹Department of Physics, Princeton University, Princeton, New Jersey 08544, USA
²Division of Infection and Immunity, University College London, London, United Kingdom
³Division of Medicine, University College London, London, United Kingdom
⁴Cancer Institute, University College London, London, United Kingdom
⁵Institute for the Physics of Living Systems, University College London, London, United Kingdom
⁶Département de Physique, École Normale Supérieure, Paris, France
⁷Department of Computer Science, University College London, London, United Kingdom
⁸Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA
⁹Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA

Unifying theories in high-dimensional biophysics: approaches, challenges and opportunities

Marianne Bauer, Akshit Goyal, Sidhartha Goyal, Gautam Reddy, Shaon Chakrabarti, Michael M. Desai, William Gilpin, Jacopo Grilli, Kabir Husain, Sanjay Jain, Mohit Kumar Jolly, Kyogo Kawaguchi, Aneta Koseska, Milo Lin, Leelavati Narlikar, Simone Pigolotti, Archishman Raju, Krishna Shrinivas, Rahul Siddharthan, Greg J. Stephens, Andreas Tiffeau-Mayer, and Suriyanarayanan Vaikuntanathan

npj Syst Biol Appl 12 43 (2026)

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Data-Driven Discovery of Biophysical T Cell Receptor Cospecificity Rules

Unifying theories in high-dimensional biophysics: approaches, challenges and opportunities

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