We derive thermodynamic speed limits for isolated quantum systems undergoing finite-time unitary driving. The key ingredient is a set of generalized second-law inequalities: for the Gibbs entropy and for several thermodynamically motivated observational entropies, the entropy production is bounded from below by a function of the Vu–Saito quantum Wasserstein distance between the initial and final coarse-grained states. These inequalities yield lower bounds on the operation time in terms of the average entropy-production rate. We apply the framework to system–bath coarse-graining, local-energy coarse-graining, and diagonal entropy, and illustrate the resulting bounds with numerical and analytically solvable examples. Our results provide a thermodynamic characterization of finite-time state transformations in isolated quantum systems and clarify how coarse-grained entropy production constrains macroscopic reachability.