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  • Letter
  • Open Access

Phase separation with nonlocal interactions

Filipe C. Thewes, Yicheng Qiang, Oliver W. Paulin, and David Zwicker*

  • *Contact author: david.zwicker@ds.mpg.de

Phys. Rev. Research 8, L022023 – Published 4 May, 2026

DOI: https://doi.org/10.1103/gdwt-v9yj

Abstract

Phase separation in complex systems is a ubiquitous phenomenon. While simple theories predict coarsening until only macroscopically large phases remain, concrete models often exhibit patterns with finite length scales. To unify such models, we here propose a general field-theoretic model that combines phase separation with nonlocal interactions. Our analysis reveals that long-range interactions generally suppress coarsening, whereas systems with nonlocal short-range interactions additionally exhibit a continuous phase transition to patterned phases. Only the latter system allows for the coexistence of homogeneous and patterned phases, which we explain by mapping to the conserved Swift-Hohenberg model. Taken together, our generic model reveals an underlying framework that describes similar phenomena observed in many complex phase-separating systems.

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References (55)

  1. M. Feric, N. Vaidya, T. S. Harmon, D. M. Mitrea, L. Zhu, T. M. Richardson, R. W. Kriwacki, R. V. Pappu, and C. P. Brangwynne, Coexisting liquid phases underlie nucleolar subcompartments, Cell 165, 1686 (2016).
  2. D. L. J. Lafontaine, J. A. Riback, R. Bascetin, and C. P. Brangwynne, The nucleolus as a multiphase liquid condensate, Nat. Rev. Mol. Cell Biol. 22, 165 (2021).
  3. J. Berry, C. P. Brangwynne, and M. Haataja, Physical principles of intracellular organization via active and passive phase transitions, Rep. Prog. Phys. 81, 046601 (2018).
  4. C. A. Weber, D. Zwicker, F. Jülicher, and C. F. Lee, Physics of active emulsions, Rep. Prog. Phys. 82, 064601 (2019).
  5. S. Alberti, Phase separation in biology, Curr. Biol. 27, R1097 (2017).
  6. C. Choi, D. A. Weitz, and C. Lee, One step formation of controllable complex emulsions: From functional particles to simultaneous encapsulation of hydrophilic and hydrophobic agents into desired position, Adv. Mater. 25, 2536 (2013).
  7. A. S. Utada, E. Lorenceau, D. R. Link, P. D. Kaplan, H. A. Stone, and D. A. Weitz, Monodisperse double emulsions generated from a microcapillary device, Science 308, 537 (2005).
  8. S. Mao, M. S. Chakraverti-Wuerthwein, H. Gaudio, and A. Košmrlj, Designing the morphology of separated phases in multicomponent liquid mixtures, Phys. Rev. Lett. 125, 218003 (2020).
  9. D. Zwicker, To mix or not to mix? Nat. Chem. Eng. 2, 152 (2025).
  10. P. J. Flory, Thermodynamics of high polymer solutions, J. Chem. Phys. 10, 51 (1942).
  11. M. L. Huggins, Solutions of long chain compounds, J. Chem. Phys. 9, 440 (1941).
  12. P. W. Voorhees, The theory of Ostwald ripening, J. Stat. Phys. 38, 231 (1985).
  13. T. Ohta and K. Kawasaki, Equilibrium morphology of block copolymer melts, Macromolecules 19, 2621 (1986).
  14. F. Liu and N. Goldenfeld, Dynamics of phase separation in block copolymer melts, Phys. Rev. A 39, 4805 (1989).
  15. T. Uneyama and M. Doi, Density functional theory for block copolymer melts and blends, Macromolecules 38, 196 (2005).
  16. K. Kawasaki and Y. Enomoto, Statistical theory of Ostwald ripening with elastic field interaction, Phys. A: Stat. Mech. Appl. 150, 463 (1988).
  17. A. Onuki and A. Furukawa, Phase transitions of binary alloys with elastic inhomogeneity, Phys. Rev. Lett. 86, 452 (2001).
  18. H. Tanaka, Viscoelastic phase separation in biological cells, Commun. Phys. 5, 167 (2022).
  19. C. Fernández-Rico, T. Sai, A. Sicher, R. W. Style, and E. R. Dufresne, Putting the squeeze on phase separation, JACS Au 2, 66 (2022).
  20. Y. Qiang, C. Luo, and D. Zwicker, Nonlocal elasticity yields equilibrium patterns in phase separating systems, Phys. Rev. X 14, 021009 (2024).
  21. O. W. Paulin, Y. Qiang, and D. Zwicker, Dynamics of phase separation in non-local elastic networks, Soft Matter 22, 1098 (2026).
  22. S. C. Glotzer, D. Stauffer, and N. Jan, Monte Carlo simulations of phase separation in chemically reactive binary mixtures, Phys. Rev. Lett. 72, 4109 (1994).
  23. J. J. Christensen, K. Elder, and H. C. Fogedby, Phase segregation dynamics of a chemically reactive binary mixture, Phys. Rev. E 54, R2212 (1996).
  24. D. Zwicker, A. A. Hyman, and F. Jülicher, Suppression of Ostwald ripening in active emulsions, Phys. Rev. E 92, 012317 (2015).
  25. Y. I. Li and M. E. Cates, Non-equilibrium phase separation with reactions: A canonical model and its behaviour, J. Stat. Mech.: Theory Exp. (2020) 053206.
  26. D. Zwicker, The intertwined physics of active chemical reactions and phase separation, Curr. Opin. Colloid Interface Sci. 61, 101606 (2022).
  27. J. Bauermann, G. Bartolucci, J. Boekhoven, F. Jülicher, and C. A. Weber, Critical transition between intensive and extensive active droplets, Phys. Rev. X 15, 041027 (2025).
  28. R. Rossetto, M. Ernst, and D. Zwicker, Exchange controls coarsening of surface condensates, arXiv:2511.03619 [physics.bio-ph] [Phys. Rev. Lett. (to be published)].
  29. C. Luo, N. Hess, D. Aierken, Y. Qiang, J. A. Joseph, and D. Zwicker, Theory of condensate size control by molecular charge asymmetry, ACS Macro Lett. 14, 1484 (2025).
  30. S. Chen, P. Zhang, and Z.-G. Wang, Complexation between oppositely charged polyelectrolytes in dilute solution: Effects of charge asymmetry, Macromolecules 55, 3898 (2022).
  31. S. Chen and Z.-G. Wang, Charge asymmetry suppresses coarsening dynamics in polyelectrolyte complex coacervation, Phys. Rev. Lett. 131, 218201 (2023).
  32. S.-F. Li and M. Muthukumar, Theory of microphase separation in concentrated solutions of sequence-specific charged heteropolymers, Macromolecules 55, 5535 (2022).
  33. Q. Yu and A. Košmrlj, Pattern formation of lipid domains in bilayer membranes, Soft Matter 21, 4288 (2025).
  34. A. Winter, Y. Liu, A. Ziepke, G. Dadunashvili, and E. Frey, Phase separation on deformable membranes: Interplay of mechanical coupling and dynamic surface geometry, Phys. Rev. E 111, 044405 (2025).
  35. R. Lefever, D. Carati, and N. Hassani, Comment on “Monte Carlo simulations of phase separation in chemically reactive binary mixtures”, Phys. Rev. Lett. 75, 1674 (1995).
  36. P. C. Hohenberg and B. I. Halperin, Theory of dynamic critical phenomena, Rev. Mod. Phys. 49, 435 (1977).
  37. M. Kardar, Statistical Physics of Fields (Cambridge University Press, Cambridge, England, 2007).
  38. R. E. A. C. Paley and N. Wiener, Fourier Transforms in the Complex Domain (American Mathematical Society, New York, 1934), Vol. 19.
  39. C. B. Muratov, Theory of domain patterns in systems with long-range interactions of Coulomb type, Phys. Rev. E 66, 066108 (2002).
  40. M. F. Hagan and G. M. Grason, Equilibrium mechanisms of self-limiting assembly, Rev. Mod. Phys. 93, 025008 (2021).
  41. M. F. Hagan and F. Mohajerani, Self-assembly coupled to liquid-liquid phase separation, PLoS Comput. Biol. 19, e1010652 (2023).
  42. C. Sagui and R. C. Desai, Kinetics of phase separation in two-dimensional systems with competing interactions, Phys. Rev. E 49, 2225 (1994).
  43. Y. Shiwa, The amplitude and phase-diffusion equations for lamellar patterns in block copolymers, Phys. Lett. A 228, 279 (1997).
  44. Y. Levin, R. Pakter, F. B. Rizzato, T. N. Teles, and F. P. Benetti, Nonequilibrium statistical mechanics of systems with long-range interactions, Phys. Rep. 535, 1 (2014).
  45. M. Tateno and H. Tanaka, Power-law coarsening in network-forming phase separation governed by mechanical relaxation, Nat. Commun. 12, 912 (2021).
  46. J. Burke and E. Knobloch, Localized states in the generalized Swift-Hohenberg equation, Phys. Rev. E 73, 056211 (2006).
  47. Y. P. Ma, J. Burke, and E. Knobloch, Defect-mediated snaking: A new growth mechanism for localized structures, Physica D 239, 1867 (2010).
  48. M. P. Holl, A. J. Archer, S. V. Gurevich, E. Knobloch, L. Ophaus, and U. Thiele, Localized states in passive and active phase-field-crystal models, IMA J. Appl. Math. 86, 896 (2021).
  49. H. Emmerich, H. Löwen, R. Wittkowski, T. Gruhn, G. I. Tóth, G. Tegze, and L. Gránásy, Phase-field-crystal models for condensed matter dynamics on atomic length and diffusive time scales: An overview, Adv. Phys. 61, 665 (2012).
  50. U. Thiele, A. J. Archer, M. J. Robbins, H. Gomez, and E. Knobloch, Localized states in the conserved Swift-Hohenberg equation with cubic nonlinearity, Phys. Rev. E 87, 042915 (2013).
  51. M. Mannattil, H. Diamant, and D. Andelman, Theory of microphase separation in elastomers, Phys. Rev. Lett. 135, 108101 (2025).
  52. C. Fernández-Rico, S. Schreiber, H. Oudich, C. Lorenz, A. Sicher, T. Sai, V. Bauernfeind, S. Heyden, P. Carrara, L. D. Lorenzis, R. W. Style, and E. R. Dufresne, Elastic microphase separation produces robust bicontinuous materials, Nat. Mater. 23, 124 (2024).
  53. F. C. Thewes, Y. Qiang, O. W. Paulin, and D. Zwicker, Phase separation with non-local interactions: Field simulations, Zenodo (2026), https://doi.org/10.5281/zenodo.18457304.
  54. J. Zhu, L.-Q. Chen, J. Shen, and V. Tikare, Coarsening kinetics from a variable-mobility Cahn-Hilliard equation: Application of a semi-implicit Fourier spectral method, Phys. Rev. E 60, 3564 (1999).
  55. B. Derrida, Microscopic versus macroscopic approaches to non-equilibrium systems, J. Stat. Mech. (2011) P01030.

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