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  • Letter
  • Open Access

Mechanical plasticity of cell membranes enhances epithelial wound closure

Andrew T. Ton1,2,*, Arthur K. MacKeith3,2, Mark D. Shattuck4, and Corey S. O'Hern3,1,5,2

  • 1Department of Physics, Yale University, New Haven, Connecticut 06520, USA
  • 2Integrated Graduate Program in Physical and Engineering Biology, Yale University, New Haven, Connecticut 06520, USA
  • 3Department of Mechanical Engineering & Materials Science, Yale University, New Haven, Connecticut 06520, USA
  • 4Benjamin Levich Institute and Physics Department, City College of New York, New York, New York 10031, USA
  • 5Department of Applied Physics, Yale University, New Haven, Connecticut 06520, USA

  • *andrew.ton@yale.edu
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Phys. Rev. Research 6, L012036 – Published 22 February, 2024

DOI: https://doi.org/10.1103/PhysRevResearch.6.L012036

Abstract

During epithelial wound healing, cell morphology near the healed wound and the healing rate vary strongly among different developmental stages even for a single species like Drosophila. We develop deformable particle (DP) model simulations to understand how variations in cell mechanics give rise to distinct wound closure phenotypes in the Drosophila embryonic ectoderm and larval wing disc epithelium. We find that plastic deformation of the cell membrane can generate large changes in cell shape consistent with wound closure in the embryonic ectoderm. Our results show that the embryonic ectoderm is best described by cell membranes with an elasto-plastic response, whereas the larval wing disc is best described by cell membranes with an exclusively elastic response. By varying the mechanical response of cell membranes in DP simulations, we recapitulate the wound closure behavior of both the embryonic ectoderm and the larval wing disc.

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Phys. Rev. Research 6, L012036– Published 22 February, 2024
  • Received 19 May 2023
  • Accepted 25 January 2024
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Published by the American Physical Society under the terms of the Creative Commons Attribution 4.0 International license. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI.

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