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  • Letter
  • Open Access

Geometrical patterning of receptor sites controls kinetics via many-body effects in bivalent systems

Richard E. Spinney1,2, Lawrence Lee2,3, and Richard G. Morris1,2

  • 1School of Physics, University of New South Wales, Sydney 2052, Australia
  • 2EMBL-Australia node in Single Molecule Science, School of Biomedical Sciences, University of New South Wales, Sydney 2052, Australia
  • 3ARC Centre of Excellence in Synthetic Biology, University of New South Wales, Sydney 2052, Australia

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Phys. Rev. Research 4, L042028 – Published 14 November, 2022

DOI: https://doi.org/10.1103/PhysRevResearch.4.L042028

Abstract

We report on the geometrical patterning of receptor sites in bi- and multi-valent systems as a modality for controlling kinetic behaviors, in both synthetic and biological contexts, that is independent of the underlying chemistry. Exploring motifs, chains, and lattices of receptor sites, we recast this phenomenon as one of many-body coordination, making contact with classical treatments of interacting systems, implicating geometric frustration as an important heuristic for rational design. In doing so, we also reveal the possibility of other tunable spatio-temporal features, such as correlation lengths, mean-squared displacements, and percolation-like transitions.

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Phys. Rev. Research 4, L042028– Published 14 November, 2022
  • Received 31 March 2022
  • Accepted 11 October 2022
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Published by the American Physical Society under the terms of the Creative Commons Attribution 4.0 International license. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI.

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