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  • Letter
  • Open Access

Many-body effect renders universal subdiffusion to water on different proteins

Song Li1, Pan Tan2, Jun Li1, Min Tang2,3, and Liang Hong1,2,*

  • 1School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai 200240, China
  • 2Institute of Natural Sciences, Shanghai Jiao Tong University, Shanghai 200240, China
  • 3School of Mathematics, Shanghai Jiao Tong University, Shanghai 200240, China

  • *Corresponding author: hongl3liang@sjtu.edu.cn
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Phys. Rev. Research 4, L022003 – Published 5 April, 2022

DOI: https://doi.org/10.1103/PhysRevResearch.4.L022003

Abstract

Diffusion of interfacial water is crucial for the function and stability of enclosed protein molecule. By combining neutron scattering and molecular dynamics simulation results, we found that the interfacial water on different proteins including intrinsically disordered proteins exhibit a universal subdiffusive motion with a common power law. Further analysis of the simulation trajectories and analytical modeling reveal that it is the many-body effect, i.e., water prefers to jump between shallow trapping sites on the protein as the deep ones are mostly occupied, that overrides the surface differences among proteins to render the interfacial water universal subdiffusion.

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Phys. Rev. Research 4, L022003– Published 5 April, 2022
  • Received 3 August 2021
  • Accepted 7 January 2022
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Published by the American Physical Society under the terms of the Creative Commons Attribution 4.0 International license. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI.

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