The Higgs field in the standard model may couple to new physics sectors related to dark matter and/or massive neutrinos. In this Letter we propose a novel signature, the boosted di-Higgs-boson plus (which is either a dark matter or neutrino), to probe those new physics sectors. In a large class of models, in particular, the supersymmetric standard models and low scale seesaw mechanisms, this signature can play a key role. The signature has a clear background, and at the high luminosity LHC, we can probe it with a production rate as low as . We apply it to benchmark models, supersymmetry in the bino-Higgsino limit, the canonical seesaw model, and the little Higgs model, finding that the masses of the Higgsino, right-handed neutrino, and heavy vector boson can be probed up to , 650, and 900 GeV, respectively.