We study the genuine multipartite entanglement (GME) in disordered system and its potential for detecting the transition from the thermalized to the localized phase. We demonstrate that the quenched average GME can approach its near-maximum value in the ergodic phase of a disordered quantum spin model. In contrast, GME vanishes in the many-body localized (MBL) phase, both in equilibrium and in the long-time dynamical regime, indicating lack of multipartite entanglement in the localized regime. To establish this, we analyze the disordered Heisenberg spin chain subjected to a random magnetic field along with the two- and three-body Dzya{}oshinskii–Moriya (DM) interactions. We exhibit that the behavior of GME, in both the mid-spectrum of the Hamiltonian and the dynamically evolved states from an initial N{'e}el configuration, serves as a reliable indicator of the critical disorder strength required for ergodic to MBL transition. The identified transition point aligns well with standard indicators such as the gap ratio and the correlation length. Moreover, we find that the presence of DM interactions, particularly the three-body interaction, significantly enlarges the thermal phase and delays the onset of localization with an extended correlation length. This shift in the transition point is consistently reflected in both static and dynamical analyses, reinforcing the GME as a robust probe for MBL transitions.