First-principles-based effective Hamiltonian simulations are used to reveal the hidden connection between various topological defects, namely point defects and skyrmions, in copper oxide selenite (${\mathrm{Cu}}_2{\mathrm{OSeO}}_3$). Using this approach, we show that (i) ${\mathrm{Cu}}_2{\mathrm{OSeO}}_3$ hosts different topological defects with a nonzero local topological charge in various regions of the magnetic-field–temperature phase diagram $(H,T)$, (ii) point defects exert external pressure on skyrmions leading to their gradual annihilation as temperature increases, and (iii) this annihilation of skyrmions is a result of the melting of the lattice into a glassylike state of spins that connects with the paramagnetic phase.

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• Dzyaloshinskii-Moriya interaction
• Magnetism
• Point defects
• Skyrmions
• Topological defects
• Topological phase transition
• Chiral magnets
• Multiferroics
• Noncollinear magnets
• Monte Carlo methods