van der Waals heterostructures based on two-dimensional materials have recently become a very active topic of research in spintronics, both aiming at a fundamental description of spin dephasing processes in nanostructures and as a potential element in spin-based information processing schemes. Here, we theoretically investigate the magnetoconductance of mesoscopic devices built from graphene proximity-coupled to a high spin-orbit coupling material. Through numerically exact tight-binding simulations, we show that the interfacial breaking of inversion symmetry generates robust weak antilocalization even when the $z\to -z$ symmetric spin-orbit coupling in the quantum dot dominates over the Bychkov-Rashba interaction. Our findings are interpreted in the light of random matrix theory, which links the observed behavior of quantum interference corrections to a transition from a circular-orthogonal to circular-symplectic ensemble.

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• Open quantum systems
• Quantum interference effects
• Spin-orbit coupling
• Spintronics
• Graphene
• Quantum billiards
• Quantum dots
• Random matrix theory
• Tight-binding model