We demonstrate high-contrast, edge-enhanced proton imaging using a relativistic hollow Laguerre-Gaussian laser (approximately ${10}^{20}\text{W}/{\text{cm}}^2$) incident on nanometer-scale CH foils. In contrast to conventional Gaussian drive, which produces a dotlike proton source, the Laguerre-Gaussian beam generates a ring-shaped proton beam that preferentially enhances peripheral features and enables high-contrast boundary imaging. As a proof of principle, we obtain a clear outline of low-($Z$) soft tissue in a beetle specimen, benefiting from the strong sensitivity of proton energy loss to modest density variations. By comparison, x-ray radiography in the same geometry primarily emphasizes high-($Z$) components (e.g., skeletal structures). Our results establish Laguerre-Gaussian-laser-driven proton radiography as a promising, complementary modality to x-ray imaging, offering improved soft tissue contrast and potential utility for medical diagnostics and radiotherapy guidance.

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• Beam optics
• Laser driven ion acceleration
• Laser-plasma interactions
• Medical imaging
• Medical applications of accelerators
• Proton & ion sources
• Particle beams
• Radiography