We present perturbative quantum chromodynamics (pQCD) predictions for the modification to the yield of high-momentum particles in very light ion collisions - ${}^{10}B+{}^{10}B$, ${}^{6}Li+{}^{6}Li$, ${}^{4}He+{}^{4}He$, and ${}^{3}He+{}^{3}He$ - both with and without medium-induced energy loss. We show that there is non-trivial suppression expected from our partonic energy loss model in symmetric systems from ${}^{208}Pb+{}^{208}Pb$ to ${}^{3}He+{}^{3}He$ and in asymmetric systems $A+B$, and that the energy loss scales approximately with $(\sqrt{AB}{)}^{1/3}$. Further, we find that deep inelastic scattering measurements in ${}^{3}He$ and ${}^{6}Li$ tightly constrain the nPDF baseline, making these isotopes a particularly clean environment for searching for final-state partonic energy loss induced by the formation of a quark-gluon plasma in these very small systems.