The light-shining-through-a-wall experiment ALPS,II at DESY in Hamburg searched for axions and similar lightweight particles in its first science campaign from February to May 2024. No evidence for the existence of such particles was found. For pseudoscalar bosons like the axion, with masses below about 0.1,meV, we achieved a limit of $|g_{\varphi \gamma \gamma }^p|<1.5\cdot {10}^{-9}Ge{V}^{-1}$ at a 95% confidence level for the di-photon coupling strength. This is more than a factor of 20 improvement compared to all previous similar experiments. We also provide limits on photon interactions for scalar, vector and tensor bosons. A further achievement of this first science campaign is the demonstration of stable operation and robust calibration of the complex experiment. Currently, the optical system of ALPS,II is being upgraded aiming for another two orders of magnitude sensitivity increase.