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Repulsive Particle Interactions Enable Selective Information Processing at Cellular Interfaces

J. Elliott1,2, H. Shah1, R. Belousov1, G. Dey1, and A. Erzberger1,2,*

  • *Contact author: erzberge@embl.de
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Phys. Rev. Lett. 135, 218403 – Published 21 November, 2025

DOI: https://doi.org/10.1103/ywr6-mzz5

Abstract

Living systems relay information across membrane interfaces to coordinate compartment functions. We identify a physical mechanism for selective information transmission that arises from the sigmoidal response of surface-bound particle densities to spatial features in adjacent external structures through a nonuniform binding energy. This mechanism implements a form of spatial thresholding, enabling the binary classification of external cues. Expansion microscopy measurements of nuclear pore complex distributions in S. arctica show signatures of such physical thresholding.

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Phys. Rev. Lett. 135, 218403– Published 21 November, 2025
  • Received 18 June 2025
  • Accepted 20 October 2025
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