Universal Model for Ion Transport: Bridging The Goldman-Hodgkin-Katz Paradigm with Reverse Electrodialysis
Phys. Rev. Lett. 134, 228401 – Published 5 June, 2025
DOI: https://doi.org/10.1103/kf5h-wtlb
Abstract
The Goldman-Hodgkin-Katz (GHK) theory has been the paradigm for ion transport in physiological systems for the past century. However, GHK incorrectly assumes a uniform electrical field, leading to several inconsistencies. We propose a new theory developed using methods from the reverse-electrodialysis (RED) community. Our theory, substantiated by simulations, provides expressions for all the main characteristics of ion transport and connects GHK to RED, providing a remarkably robust framework for (re-)interpreting ion transport experiments in any (living or inanimate) charge-selective system.
Physics Subject Headings (PhySH)
See Also
Goldman-Hodgkin-Katz equation, reverse electrodialysis, and everything in between
Phys. Rev. E 111, 064408 (2025)
