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    Universal Persistent Brownian Motions in Confluent Tissues

    Alessandro Rizzi and Sangwoo Kim*

    • *Contact author: sangwoo.kim@epfl.ch

    Phys. Rev. Lett. 136, 158401 – Published 13 April, 2026

    DOI: https://doi.org/10.1103/g6l8-wbt1

    Abstract

    Biological tissues are active materials whose nonequilibrium dynamics emerge from distinct cellular force-generating mechanisms. Using a two-dimensional active foam model, we compare the effects of traction forces and junctional tension fluctuations on confluent tissue dynamics. While these two modes of activity produce qualitatively different cell shapes, rearrangement statistics, and spatiotemporal correlations in fluid states, we find that the long-time cellular motion universally converges to persistent Brownian dynamics. This universal feature contrasts with the nonuniversal correlations between cell geometry, rearrangement rate, and fluidity, which depend sensitively on the underlying modes of active force. Our results demonstrate that persistent Brownian motion provides a minimal framework for describing tissue dynamics, while distinct active forces leave identifiable structural and dynamical signatures, thereby enabling inference of the dominant active force in fluid state tissues.

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