Probing the Mechanical Unzipping of DNA

N. K. Voulgarakis, A. Redondo, A. R. Bishop, and K. Ø. Rasmussen
Phys. Rev. Lett. 96, 248101 – Published 21 June 2006

Abstract

A study of the micromechanical unzipping of DNA in the framework of the Peyrard-Bishop-Dauxois model is presented. We introduce a Monte Carlo technique that allows accurate determination of the dependence of the unzipping forces on unzipping speed and temperature. Our findings agree quantitatively with experimental results for homogeneous DNA, and for λ-phage DNA we reproduce the recently obtained experimental force-temperature phase diagram. Finally, we argue that there may be fundamental differences between in vivo and in vitro DNA unzipping.

  • Figure
  • Figure
  • Figure
  • Figure
  • Received 20 December 2005

DOI:https://doi.org/10.1103/PhysRevLett.96.248101

©2006 American Physical Society

Authors & Affiliations

N. K. Voulgarakis, A. Redondo, A. R. Bishop, and K. Ø. Rasmussen

  • Theoretical Division and Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA

Article Text (Subscription Required)

Click to Expand

References (Subscription Required)

Click to Expand
Issue

Vol. 96, Iss. 24 — 23 June 2006

Reuse & Permissions
Access Options
Collection
Heating up of Superconductors
January 27, 2017

This collection marks the 30th anniversary of the discovery of high-temperature superconductors. The papers selected highlight some of the advances that have been made to date, both in understanding why these compounds behave in the way they do, and in utilizing them in applications. The papers included in the collection have been made free to read.

APS and CERN Sign Open Access Agreement for SCOAP3

APS and CERN, the host organization of SCOAP3 (Sponsoring Consortium for Open Access Publishing in Particle Physics), have signed an agreement to make the high-energy physics (HEP) articles published in three leading APS journals open access beginning January 1, 2018. This agreement acts to support the publishing of open access content for wider benefit of the HEP community.

Authorization Required


×
×

Images

×

Sign up to receive regular email alerts from Physical Review Letters

Log In

Cancel
×

Search


Article Lookup

Paste a citation or DOI

Enter a citation
×