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    Three-Dimensional Chiral Active Ornstein-Uhlenbeck Model for Helical Motion of Microorganisms

    Leon Lettermann1,2, Falko Ziebert1,2, Mirko Singer3, Friedrich Frischknecht3,4, and Ulrich S. Schwarz1,2,*

    • 1Institute for Theoretical Physics, Heidelberg University, Philosophenweg 19, 69120 Heidelberg, Germany
    • 2Bioquant-Center, Heidelberg University, Im Neuenheimer Feld 267, 69120 Heidelberg, Germany
    • 3Parasitology, Center for Infectious Diseases, Heidelberg University, Im Neuenheimer Feld 344, 69120 Heidelberg, Germany
    • 4German Center for Infection Research (DZIF), Partner Site Heidelberg, 69120 Heidelberg, Germany

    • *Contact author: schwarz@thphys.uni-heidelberg.de

    Phys. Rev. Lett. 135, 128403 – Published 18 September, 2025

    DOI: https://doi.org/10.1103/4kxb-h6p4

    Abstract

    Active movement is essential for the survival of microorganisms like bacteria, algae, and unicellular parasites. In three dimensions, both swimming and gliding microorganisms often exhibit helical trajectories. One such case are malaria parasites gliding through 3D hydrogels, for which we find that the internal correlation time for the stochastic process generating propulsion is similar to the time taken for one helical turn. Motivated by this experimental finding, here we theoretically analyze the case of finite internal correlation time for microorganisms with helical trajectories as chiral active particles with an Ornstein-Uhlenbeck process for torque. We present an analytical solution which is in very good agreement with computer simulations. We then show that, for this type of internal noise, chirality and rotation increase the persistence of motion and results in helical trajectories that have a larger long-time mean squared displacement than straight trajectories at the same propulsion speed. Finally, we provide experimental evidence for this prediction for the case of malaria parasites.

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