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Double multiturn injection scheme for generating mixed helium and carbon ion beams at medical synchrotron facilities

Matthias Kausel1,2,*, Claus Schmitzer1, Andreas Gsponer3,2, Markus Wolf1, Hermann Fuchs4, Felix Ulrich-Pur5, Thomas Bergauer3, Albert Hirtl2, Nadia Gambino1 et al.

Elisabeth Renner2

  • *Contact author: matthias.kausel@medaustron.at.

Phys. Rev. Accel. Beams 28, 111001 – Published 19 November, 2025

DOI: https://doi.org/10.1103/t3b5-1xb6

Abstract

The low relative charge-to-mass ratio offset of 0.065% between fully ionized helium-4 and carbon-12 ions enables simultaneous acceleration in hadron therapy synchrotrons. At the same energy per mass, helium ions exhibit a stopping range approximately 3 times greater than carbon ions. They can therefore be exploited for online range verification downstream of the patient during carbon ion beam irradiation. One possibility for creating this mixed beam is accelerating the two ion species sequentially through the LINAC and subsequently “mixing” them at injection energy in the synchrotron with a double multiturn injection scheme. This work reports the first successful generation, acceleration, and extraction of a mixed helium and carbon ion beam using this double multiturn injection scheme, which was achieved at the MedAustron therapy accelerator in Austria. A description of the double multiturn injection scheme, particle tracking simulations, and details on the implementation at the MedAustron accelerator facility are presented and discussed. Finally, measurements of the mixed beam at delivery in the irradiation room using a radiochromic film and a low-gain avalanche diode detector are presented.

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References (35)

  1. C. Graeff, U. Weber, C. Schuy, N. Saito, L. Volz, P. Piersimoni, J. Seco, and M. Kraemer, Helium as a range probe in carbon ion therapy, Phys. Med. 52, 11 (2018).
  2. D. Mazzucconi, S. Agosteo, M. Ferrarini, L. Fontana, V. Lante, M. Pullia, and S. Savazzi, Mixed particle beam for simultaneous treatment and online range verification in carbon ion therapy: Proof-of-concept study, Med. Phys. 45, 5234 (2018).
  3. L. Volz, L. Kelleter, S. Brons, L. Burigo, C. Graeff, N. I. Niebuhr, R. Radogna, S. Scheloske, C. Schömers, S. Jolly, and J. Seco, Experimental exploration of a mixed helium/carbon beam for online treatment monitoring in carbon ion beam therapy, Phys. Med. Biol. 65, 055002 (2020).
  4. J. J. Hardt, A. A. Pryanichnikov, N. Homolka, E. A. DeJongh, D. F. DeJongh, R. Cristoforetti, O. Jäkel, J. Seco, and N. Wahl, The potential of mixed carbon–helium beams for online treatment verification: A simulation and treatment planning study, Phys. Med. Biol. 69, 125028 (2024).
  5. M. Galonska, W. Barth, C. Graeff, R. Hollinger, F. Maimone, D. Ondreka, S. Reimann, M. Schanz, J. Stadlmann, P. Spiller, D. Varentsov, L. Volz, and T. Wagner, First dual isotope beam production for simultaneous heavy ion radiotherapy and radiography, in Proceedings of the 15th International Particle Accelerator Conference, IPAC-2024, Nashville, TN (JACoW, Geneva, Switzerland, 2024), pp. 1893–1896.
  6. D. Ondreka, L. Bozyk, C. Graeff, P. Spiller, J. Stadlmann, and L. Volz, Slow extraction of a dual-isotope beam from SIS18, in Proceedings of the 15th International Particle Accelerator Conference, IPAC-2024, Nashville, TN (JACoW, Geneva, Switzerland, 2024), pp. 1698–1701.
  7. T. Haberer, J. Debus, H. Eickhoff, O. Jäkel, D. Schulz-Ertner, and U. Weber, The Heidelberg ion therapy center, Radiother. Oncol. 73, 186 (2004).
  8. U. Amaldi, CNAO-The Italian centre for light-ion therapy, Radiother. Oncol. 73, 191 (2004).
  9. M. Benedikt, Challenges and Goals for Accelerators in the XXI Century (World Scientific, Singapore, 2016), pp. 813–824.
  10. L. Badano, M. Benedikt, P. J. Bryant, M. Crescenti, P. Holy, A. T. Maier, M. Pullia, S. Rossi, and P. Knaus, Proton-ion medical machine study (PIMMS), 1, Technical Report No. CERN-PS-99-010-DI, CERN, Geneva, Switzerland, 2000.
  11. P. J. Bryant, L. Badano, M. Benedikt, M. Crescenti, P. Holy, A. T. Maier, M. Pullia, S. Reimoser, S. Rossi, G. Borri, P. Knaus, F. Gramatica, M. Pavlovic, and L. Weisser, Proton-ion medical machine study (PIMMS), 2, Technical Report No. CERN-PS-2000-007-DR, CERN, Geneva, Switzerland, 2000.
  12. M. T. F. Pivi, L. Adler, A. De Franco, F. Farinon, N. Gambino, G. Guidoboni, G. Kowarik, M. Kronberger, C. Kurfürst, H. T. Lau, S. Myalski, S. Nowak, L. Penescu, C. Schmitzer, I. Strašík, P. Urschütz, and A. Wastl, Status of the carbon commissioning and roadmap projects of the MedAustron ion therapy center accelerator, in Proceedings of the 10th International Particle Accelerator Conference, IPAC-2019, Melbourne, Australia (JACoW, Geneva, Switzerland, 2019), pp. 3404–3407.
  13. N. Gambino, G. Guidoboni, M. Kausel, M. T. F. Pivi, F. Plassard, V. Rizzoglio, I. Strasik, L. Fischl, D. Prokopovich, L. Penescu, and H. Fuchs, Status of helium ion beams commissioning at MedAustron ion therapy center, in Proceedings of the 15th International Particle Accelerator Conference, IPAC-2024, Nashville, TN (JACoW, Geneva, Switzerland, 2024), pp. 1637–1640.
  14. L. Badano and S. Rossi, Characteristics of a betatron core for extraction in a proton-ion medical synchrotron, Technical Report No. CERN-PS-97-019-DI, CERN, Geneva, 1997.
  15. E. Renner, M. Kausel, F. Plassard, F. Kuehteubl, C. Schmitzer, M. Wolf, and V. Kirchweger, Towards the slow extraction of mixed He2+ and C6+ beams for online range verification, in Proceedings of the 15th International Particle Accelerator Conference, IPAC-2024, Nashville, TN (JACoW, Geneva, Switzerland, 2024), pp. 3597–3600.
  16. F. Kühteubl, Slow extraction optimisation for the MedAustron Synchrotron, Ph.D. thesis, TU Wien, 2024.
  17. T. Schreiner, M. Stock, P. Georg, and D. Georg, MedAustron: First years of operation, Nucl. Phys. News 29, 22 (2019).
  18. M. T. F. Pivi, L. Adler, G. Guidoboni, G. Kowarik, C. Kurfürst, C. Maderböck, M. Pavlovič, D. Prokopovich, M. Pullia, V. Rizzoglio, and I. Strašík, Commissioning of a gantry beamline with rotator at a synchrotron-based ion therapy center, Phys. Rev. Accel. Beams 27, 023503 (2024).
  19. Pantechnik S.A., 2013, www.pantechnik.com [accessed on November 6, 2024].
  20. G. Castro, L. Celona, F. Chines, G. Costanzo, S. Gammino, O. Leonardi, L. Malferrari, A. Massara, C. Maugeri, L. Neri, F. Odorici, S. Passarello, R. Reitano, F. Russo, and D. Siliato, The AISHa ion source at INFN-LNS, J. Phys. Conf. Ser. 2244, 012025 (2022).
  21. M. Kausel, E. Renner, C. Schmitzer, M. Wolf, N. Gambino, F. Plassard, V. Rizzoglio, I. Strasik, and V. Kirchweger, A double multi-turn injection scheme for mixed C126+ and He62+ beams, in Proceedings of the 15th International Particle Accelerator Conference, IPAC-2024, Nashville, TN (JACoW, Geneva, Switzerland, 2024), pp. 3599–3602.
  22. G. Iadarola et al., Xsuite: An integrated beam physics simulation framework, in Proceedings of the 68th ICFA Advanced Beam Dynamics workshop on high-Intensity and High-Brightness Hadron Beams, HB-2023, CERN, Geneva, Switzerland (JACoW, Geneva, Switzerland, 2024), pp. 73–80.
  23. M. T. F. Pivi and A. Garonna, Space charge effect estimation for synchrotrons with third-order resonant extraction, in Proceedings of the 6th International Particle Accelerator Conference, IPAC2015, Richmond, VA (JACoW, Geneva, Switzerland, 2015), pp. 3677–3679.
  24. M. Repovž, A. Bardorfer, B. Baričevič, M. Cerv, C. Kurfürst, G. Muyan, S. Myalski, P. Paglovec, A. Pozenel, C. Schmitzer, M. Škabar, and M. Wolf, Development of a new measurement system for beam position pickups in the LINAC and beam energy measurement (time of flight) in the MEBT for MedAustron, in Proceedings of the 11th International Beam Instrumentation Conference, Kraków, Poland (JACoW, Geneva, Switzerland, 2022), pp. 238–240.
  25. F. Osmic, M. Feurstein, A. Gyorgy, A. Kerschbaum, M. Repovž, S. Schwarz, W. Neustadt, and G. Burtin, Overview of the beam diagnostics in the MedAustron accelerator: Design choices and test beam commissioning, in Proceedings of the 3rd International Particle Accelerator Conference, New Orleans, LA, 2012 (IEEE, Piscataway, NJ, 2012), pp. 774–776.
  26. E. Renner, A. Gsponer, C. Schmitzer, D. Prokopovich, F. Plassard, F. Kuehteubl, K. Knoll, and S. Waid, Investigating pulsed slow extraction schemes at the MedAustron synchrotron, in Proceedings of the 15th International Particle Accelerator Conference, IPAC-2024, Nashville, TN (JACoW, Geneva, Switzerland, 2024), pp. 3595–3598.
  27. F. Kuehteubl, E. Renner, L. Adler, L. Fischl, X. German, G. Guidoboni, K. Holzfeind, C. Kurfuerst, C. Maderböck, M. T. F. Pivi, F. Plassard, D. Prokopovich, V. Rizzoglio, I. Strasik, C. Schmitzer, A. Wastl, P. A. Arrutia Sota, and M. Fraser, Investigating alternative extraction methods at MedAustron, in Proceedings of the 14th International Particle Accelerator Conference, IPAC-2023, Venice, Italy (JACoW, Geneva, Switzerland, 2023), pp. 2419–2422.
  28. Ashland advanced materials GAFchromic, 2024, www.gafchromic.com [accessed on November 6, 2024].
  29. J. F. Ziegler, M. Ziegler, and J. Biersack, srim–The stopping and range of ions in matter (2010), Nucl. Instrum. Methods Phys. Res., Sect. B 268, 1818 (2010)..
  30. V. Sola, R. Arcidiacono, M. Boscardin, N. Cartiglia, G.-F. Dalla Betta, F. Ficorella, M. Ferrero, M. Mandurrino, L. Pancheri, G. Paternoster, and A. Staiano, First FBK production of 50  μm ultra-fast silicon detectors, Nucl. Instrum. Methods Phys. Res., Sect. A, 924, 360 (2019).
  31. S. Waid, A. Gsponer, E. Renner, C. Schmitzer, F. Kühteubl, C. Becker, J. Burin, P. Gaggl, D. Prokopovich, and T. Bergauer, Pulsed rf knock-out extraction: A potential enabler for FLASH hadrontherapy in the Bragg peak, Phys. Med. Biol. 69, 125007 (2024).
  32. M. Kausel, C. Schmitzer, K. Holzfeind, C. Becker, and E. Renner, Recent developments in delivering mixed helium and carbon ion beams at MedAustron, in Proceedings of the 16th International Particle Accelerator Conference, Taipei, Taiwan (JACoW, Geneva, Switzerland, 2025), pp. 1147–1150.
  33. M. Benedikt, P. Collier, V. Mertens, J. Poole, and K. Schindl, LHC design reports, CERN Yellow Report No. CERN-2004-003-V-3, CERN, Geneva, 2004.
  34. J. J. Hardt, A. A. Pryanichnikov, O. Jäkel, J. Seco, and N. Wahl, Helium range viability for online range probing in mixed carbon-helium beams, arXiv:2505.01165.
  35. P. J. Bryant and K. Johnsen, The Principles of Circular Accelerators and Storage Rings, 1st ed. (Cambridge University Press, Cambridge, England, 1993).

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