Macroscopic quantum superpositions are widely believed to be unobservable because large systems cannot be perfectly isolated from their environments. Here, we show that even under perfect isolation, intrinsic unitary dynamics in generic many-body systems, as analyzed through the eigenstate thermalization hypothesis and random matrix theory, can suppress the observable signatures of macroscopic coherence. Using the Greenberger-Horne-Zeilinger state as a representative example, we demonstrate that while fully correlated measurements can initially distinguish a macroscopic superposition from its corresponding classical mixture, generic many-body evolution renders them operationally indistinguishable for most times. By analyzing both distinguishability measures and established quantifiers of macroscopic quantumness, we find that equilibration not only hides coherence from accessible observables but also suppresses the corresponding signatures of macroscopic quantumness, in particular within the additive-local framework considered here. These results identify unitary thermalization, independent of environmental decoherence, as a fundamental mechanism that limits the observation of macroscopic quantum effects.

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• Eigenstate thermalization
• Quantum coherence & coherence measures
• Quantum foundations
• Quantum-to-classical transition