• Featured in Physics

Thermal, Autonomous Replicator Made from Transfer RNA

Phys. Rev. Lett. 108, 238104 – Published 4 June 2012
Hubert Krammer, Friederike M. Möller, and Dieter Braun
Physics logo See Synopsis: Thermal Cycling Drives a Fast RNA Replicator

Abstract

Evolving systems rely on the storage and replication of genetic information. Here we present an autonomous, purely thermally driven replication mechanism. A pool of hairpin molecules, derived from transfer RNA replicates the succession of a two-letter code. Energy is first stored thermally in metastable hairpins. Thereafter, energy is released by a highly specific and exponential replication with a duplication time of 30 s, which is much faster than the tendency to produce false positives in the absence of template. Our experiments propose a physical rather than a chemical scenario for the autonomous replication of protein encoding information in a disequilibrium setting.

DOI: http://dx.doi.org/10.1103/PhysRevLett.108.238104

  • Figure
  • Figure
  • Figure
  • Figure
  • Received 18 March 2012
  • Published 4 June 2012

© 2012 American Physical Society

Synopsis

Key Image

Thermal Cycling Drives a Fast RNA Replicator

Published 4 June 2012

Could thermal conditions have been enough to drive fast RNA replication in prebiotic liquids?

See more in Physics

Authors & Affiliations

Hubert Krammer, Friederike M. Möller, and Dieter Braun

  • Systems Biophysics, Physics Department, Center for Nanoscience, Ludwig Maximilians Universität München, Amalienstrasse 54, 80799 München, Germany

Article Text (Subscription Required)

Click to Expand

Supplemental Material (Subscription Required)

References (Subscription Required)

Authorization Required


×
×

Images

×

Log In

Cancel
×

Search


Article Lookup
Paste a citation or DOI

Enter a citation
×