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Conformation and dynamics of single DNA molecules in parallel-plate slit microchannels

Phys. Rev. E 70, 060901(R) – Published 13 December 2004
Y.-L. Chen, M. D. Graham, J. J. de Pablo, G. C. Randall, M. Gupta, and P. S. Doyle


The conformation and diffusion of a single DNA molecule confined between two parallel plates are examined using both single molecule experiments and Brownian dynamics simulations accounting for hydrodynamic interactions. The degree of chain stretching and the diffusivity are characterized as a function of the chain confinement and the channel geometry. Good agreement is found between the simulations, experiments, and scaling theory predictions.

DOI: http://dx.doi.org/10.1103/PhysRevE.70.060901

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  • Received 20 August 2004
  • Published 13 December 2004

© 2004 The American Physical Society

Authors & Affiliations

Y.-L. Chen, M. D. Graham*, and J. J. de Pablo

  • Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53703, USA

G. C. Randall, M. Gupta, and P. S. Doyle

  • Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA

  • *Electronic address: graham@engr.wisc.edu
  • Electronic address: depablo@engr.wisc.edu
  • Electronic address: pdoyle@mit.edu

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